CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039616
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SH3 domain and tetratricopeptide repeat-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 SH3TC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
371QETLQKVKNVLEQCKubiquitination[1]
543RKQKNREKCAQVVPKubiquitination[1]
798NMVAVALKRTGRTRQubiquitination[1]
971LGTERAYKSALDYTKubiquitination[1]
978KSALDYTKRSLGIFIubiquitination[1]
1053DGAWEREKAVSFYRDubiquitination[1, 2]
1220NFLLDREKSLFFYQKubiquitination[1]
1227KSLFFYQKARTFATEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1260 AA 
Protein Sequence
MGVYPTDLTL QLLAVRRKSR LRDPGLQQTL RGQLRLLEND SREMARVLGE LSARLLSIHS 60
DQDRIVVTFK TFEEIWKFST YHALGFTHHC LANLLMDQAF WLLLPSEEEE TAIQVHVDEN 120
ALRLTHESLL IQEGPFFVLC PDHHVRVMTG PRDAGNGPQA LRQASGAPQG EAAPETDSSP 180
PSPSVSSEEV AVAAAPEPLI PFHQWALRIP QDPIDDAMGG PVMPGNPLMA VGLASALADF 240
QGSGPEEMTF RGGDLIEILG AQVPSLPWCV GRHAASGRVG FVRSSLISMQ GPVSELESAI 300
FLNEEEKSFF SEGCFSEEDA RQLLRRMSGT DVCSVYSLDS VEEAETEQPQ EKEIPPPCLS 360
LEPQETLQKV KNVLEQCKTC PGCPQEPASW GLCAASSDVS LQDPEEPSFC LEAEDDWEDP 420
EALSSLLLFL NAPGYKASFR GLYDVALPWL SSVFRSFSDE EELTGRLAQA RGAAKKAGLL 480
MALARLCFLL GRLCSRRLKL SQARVYFEEA LGALEGSFGD LFLVVAVYAN LASIYRKQKN 540
REKCAQVVPK AMALLLGTPD HICSTEAEGE LLQLALRRAV GGQSLQAEAR ACFLLARHHV 600
HLKQPEEALP FLERLLLLHR DSGAPEAAWL SDCYLLLADI YSRKCLPHLV LSCVKVASLR 660
TRGSLAGSLR SVNLVLQNAP QPHSLPAQTS HYLRQALASL TPGTGQALRG PLYTSLAQLY 720
SHHGCHGPAI TFMTQAVEAS AIAGVRAIVD HLVALAWLHV LHGQSPVALD ILQSVRDAVV 780
ASEDQEGVIA NMVAVALKRT GRTRQAAESY YRALRVARDL GQQRNQAVGL ANFGALCLHA 840
GASRLAQHYL LEAVRLFSRL PLGECGRDFT HVLLQLGHLC TRQGPAQQGK GYYEWALLVA 900
VEMGHVESQL RAVQRLCHFY SAVMPSEAQC VIYHELQLSL ACKVADKVLE GQLLETISQL 960
YLSLGTERAY KSALDYTKRS LGIFIDLQKK EKEAHAWLQA GKIYYILRQS ELVDLYIQVA 1020
QNVALYTGDP NLGLELFEAA GDIFFDGAWE REKAVSFYRD RALPLAVTTG NRKAELRLCN 1080
KLVALLATLE EPQEGLEFAH MALALSITLG DRLNERVAYH RLAALQHRLG HGELAEHFYL 1140
KALSLCNSPL EFDEETLYYV KVYLVLGDII FYDLKDPFDA AGYYQLALAA AVDLGNKKAQ 1200
LKIYTRLATI YHNFLLDREK SLFFYQKART FATELNVRRV NLPPLPLCGW APWLAPSHPR 1260 
Gene Ontology
  
Interpro
 IPR001452; SH3_domain.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
  
SMART
 SM00326; SH3
 SM00028; TPR 
PROSITE
 PS50002; SH3 
PRINTS