CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Craniofacial development protein 1 
Protein Synonyms/Alias
 Bucentaur 
Gene Name
 CFDP1 
Gene Synonyms/Alias
 BCNT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
167TEKVKITKVFDFAGEubiquitination[1, 2, 3, 4, 5]
200FKQNEKEKPQANVPSacetylation[6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 May play a role during embryogenesis (By similarity). 
Sequence Annotation
 DOMAIN 218 299 BCNT-C.
 REGION 178 217 Hydrophilic.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 250 250 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MEEFDSEDFS TSEEDEDYVP SGGEYSEDDV NELVKEDEVD GEEQTQKTQG KKRKAQSIPA 60
RKRRQGGLSL EEEEEEDANS ESEGSSSEEE DDAAEQEKGI GSEDARKKKE DELWASFLND 120
VGPKSKVPPS TQVKKGEETE ETSSSKLLVK AEELEKPKET EKVKITKVFD FAGEEVRVTK 180
EVDATSKEAK SFFKQNEKEK PQANVPSALP SLPAGSGLKR SSGMSSLLGK IGAKKQKMST 240
LEKSKLDWES FKEEEGIGEE LAIHNRGKEG YIERKAFLDR VDHRQFEIER DLRLSKMKP 299 
Gene Ontology
 GO:0007155; P:cell adhesion; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara. 
Interpro
 IPR011421; BCNT-C.
 IPR027124; Swc5/CFDP. 
Pfam
 PF07572; BCNT 
SMART
  
PROSITE
 PS51279; BCNT_C 
PRINTS