CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035275
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenosylhomocysteinase 
Protein Synonyms/Alias
  
Gene Name
 Ahcyl2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
193DFCVKNIKQAEFGRRacetylation[1]
223RKRAQGEKPLAGAKIacetylation[1]
348HRLYQLSKAGKLCVPacetylation[1]
440MDGFRLVKLNEVIRQacetylation[1]
559NAPEGRYKQDVYLLPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; NAD; One-carbon metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 611 AA 
Protein Sequence
MSVQVVSAAA AAKVPEVELK DLSPSEAEPQ LGLSTATVGA MVPPAGGGDP EAPAPAPAAE 60
RPPAPGPGSG PTAALSPAAG KVPQASAMKR SDPHHQHQRH RDGGEALVSP DGTVTEAPRT 120
VKKIQFADQK QEFNKRPTKI GRRSLSRSIS QSSTDSYSSA ASYTDSSDDE TSPRDKQQKN 180
SKGSSDFCVK NIKQAEFGRR EIEIAEQEMP ALMALRKRAQ GEKPLAGAKI VGCTHITAQT 240
AVLMETLGAL GAQCRWAACN IYSTLNEVAA ALAESGFPVF AWKGESEDDF WWCIDRCVNV 300
EGWQPNMVVE AGQEAFAFII SSLKSMMTLL FGIVESVTGV HRLYQLSKAG KLCVPAMNVN 360
DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSVVYV 420
TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH 480
SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA 540
TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK 600
NGPFKPNYYR Y 611 
Gene Ontology
 GO:0004013; F:adenosylhomocysteinase activity; IEA:EC.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 
Pfam
 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 
SMART
 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 
PROSITE
 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 
PRINTS