| Tag | Content |
|---|
| CPLM ID | CPLM-016060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative ATP-dependent RNA helicase DHX33 |
Protein Synonyms/Alias | DEAH box protein 33 |
Gene Name | Dhx33 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 416 | YTEDEFEKFEKMTVP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization (By similarity). |
Sequence Annotation | DOMAIN 75 243 Helicase ATP-binding.
DOMAIN 271 441 Helicase C-terminal.
NP_BIND 88 95 ATP (By similarity).
MOTIF 185 188 DEAH box.
MOTIF 536 550 Critical for rDNA-binding.
MOD_RES 125 125 Phosphoserine. |
Keyword | ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 698 AA |
Protein Sequence | MPEEASLPPA KRFRPGSCPP GRRVVMLLTA GGGGGAGGGR RQTPPLAQPS ASPYREALEL 60
QRRSLPIFRA RGQLLAQLRN LDNAVLIGET GSGKTTQIPQ YLYEGGISRQ GIIAVTQPRR 120
VAAISLATRV SDEKRTELGK LVGYTVRFED VTSEDTRIKF LTDGMLLREA ISDSLLRKYS 180
CVILDEAHER TIHTDVLFGV VKTAQKRRKE LGKLPLKVIV MSATMDVDLF SQYFNRAPVL 240
YLEGRQHPIQ IFYTKQPQQD YLHAALVSVF QIHQEAPASQ DILVFLTGQE EIEAMSKTCR 300
DIARHLPDGC PSMLVLPLYA SLPYSQQLRV FQGAPKGYRK VIISTNIAET SITITGIKYV 360
VDTGMVKAKK YNPDSGLEVL AVQRVSKTQA WQRTGRAGRE DSGICYRLYT EDEFEKFEKM 420
TVPEIQRCNL ASVILQLLAM KVPNVLTFDF MSKPSPDHIE AAIAQLDLLG ALEHKDDQLT 480
LTPIGRKMAA FPLEPRFAKT ILLSSKFHCT EEILTIVSLL SVDSVLYNPP ARRDEVQSVR 540
KKFISSEGDH ITLLNIYRTF KNIGGNKDWC KENFVNSKNM LLVAEVRAQL REICLKMSMP 600
IMSSRGDMES VRRCMAHSLF MNTAELQTDG TYATTDTHQP VAIHPSSVLF HCKPACVVYT 660
SLLYTNKCYM RDLCVVDAEW LYEAAPDYFR RKLRTARN 698 |
Gene Ontology | GO:0005730; C:nucleolus; IDA:UniProtKB. GO:0005654; C:nucleoplasm; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0000182; F:rDNA binding; IDA:UniProtKB. GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |