UniProt Accession

 CX1_NAJPA; P01468 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Cytotoxin 1 

Protein Synonyms/Alias

 Cardiotoxin gamma 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Naja pallida (Red spitting cobra) 

NCBI Taxa ID

 8658 

Lysine Modification

Position	Peptide	Type	References
2	******LKCNQLIPP	acetylation	[1]
12	QLIPPFWKTCPKGKN	acetylation	[1]
23	KGKNLCYKMTMRAAP	acetylation	[1]
35	AAPMVPVKRGCIDVC	acetylation	[1]

Reference

 [1] Delineation of the functional site of a snake venom cardiotoxin: preparation, structure, and function of monoacetylated derivatives.
 Gatineau E, Takechi M, Bouet F, Mansuelle P, Rochat H, Harvey AL, Montenay-Garestier T, Ménez A.
 Biochemistry. 1990 Jul 10;29(27):6480-9. [PMID: 2207089] 

Functional Description

 Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity (By similarity). 

Sequence Annotation

 DISULFID 3 21
 DISULFID 14 38
 DISULFID 42 53
 DISULFID 54 59  

Keyword

 3D-structure; Cardiotoxin; Cytolysis; Direct protein sequencing; Disulfide bond; Hemolysis; Secreted; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 60 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
 GO:0044179; P:hemolysis in other organism; IEA:UniProtKB-KW. 

Interpro

 IPR003572; Cytotoxin.
 IPR003571; Snake_toxin.
 IPR018354; Snake_toxin_BS. 

Pfam

 PF00087; Toxin_1 

SMART

  

PROSITE

 PS00272; SNAKE_TOXIN 

PRINTS

 PR00282; CYTOTOXIN.