| Tag | Content |
|---|
| CPLM ID | CPLM-020792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF128 |
Protein Synonyms/Alias | Gene related to anergy in lymphocytes protein; Goliath-related E3 ubiquitin-protein ligase 1; RING finger protein 128 |
Gene Name | Rnf128 |
Gene Synonyms/Alias | Grail; Greul1; MNCb-3816 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 257 | DAKKAIGKLQLRTLK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals (By similarity). |
Sequence Annotation | DOMAIN 75 183 PA.
ZN_FING 277 318 RING-type; atypical.
CARBOHYD 48 48 N-linked (GlcNAc...) (Potential).
CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).
CARBOHYD 101 101 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Cytoplasm; Glycoprotein; Ligase; Membrane; Metal-binding; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MGPPPGIGVY CRGGCGAARL LAWCFLLALS PHAPGSRGAE AVWTAYLNVS WRVPHTGVNR 60
TVWELSEEGV YGQDSPLEPV SGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI 120
QRGGGCTFAD KIHLASERGA SGAVIFNFPG TRNEVIPMSH PGAGDIVAIM IGNLKGTKIL 180
QSIQRGIQVT MVIEVGKKHG PWVNHYSIFF VSVSFFIITA ATVGYFIFYS ARRLRNARAQ 240
SRKQRQLKAD AKKAIGKLQL RTLKQGDKEI GPDGDSCAVC IELYKPNDLV RILTCNHIFH 300
KTCVDPWLLE HRTCPMCKCD ILKALGIEVD VEDGSVSLQV PVSNEASNTA SPHEEDSRSE 360
TASSGYASVQ GADEPPLEEH AQSANENLQL VNHEANSVAV DVVPHVDNPT FEEDETPDQE 420
AAVREIKS 428 |
Gene Ontology | GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0005783; C:endoplasmic reticulum; IDA:MGI. GO:0005794; C:Golgi apparatus; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005770; C:late endosome; IDA:MGI. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0042036; P:negative regulation of cytokine biosynthetic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |