UniProt Accession

 PGFS_HUMAN; Q8TBF2; A8K793; B3KPY3; B4DQR9; B4E0S5; B7ZAC8; B9DI90; B9DI92; Q8N2H0 

Genbank Protein ID

 AK057027; AK075273; AK291908; AK298926; AK303504; AK316243; AF425266; AL139246; AL139246; AL139246; CH471183; CH471183; CH471183; BC022547 

Genbank Nucleotide ID

 BAG51845.1; BAC11511.1; BAF84597.1; BAG61031.1; BAG64537.1; BAH14614.1; AAP97295.1; CAX30825.1; CAX30826.1; CAX30827.1; EAW56086.1; EAW56087.1; EAW56088.1; AAH22547.1 

Protein Name

 Prostamide/prostaglandin F synthase 

Protein Synonyms/Alias

 Prostamide/PG F synthase; Prostamide/PGF synthase; Protein FAM213B 

Gene Name

 FAM213B 

Gene Synonyms/Alias

 C1orf93 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	DESKQLYKELGFKRL	ubiquitination	[1]
138	ILPAALGKPVRDVAA	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). 

Sequence Annotation

 MOD_RES 108 108 Phosphotyrosine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome. 

Interpro

  

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