UniProt Accession

 SEP11_HUMAN; Q9NVA2; B7Z7Z6; E9KL32; Q4W5G1; Q7L4N1; Q96SP1; Q9UFY9 

Genbank Protein ID

 GU727629; AK001711; AK027633; AK302700; AC104687; AC111196; CH471057; BC008083; BC063615; AL110300 

Genbank Nucleotide ID

 ADU87631.1; BAA91853.1; BAB55250.1; BAH13782.1; AAY40922.1; EAX05805.1; AAH08083.3; AAH63615.1; CAB53741.2 

Protein Name

 Septin-11 

Protein Synonyms/Alias

  

Gene Name

 SEPT11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
315	KDTDPDSKPFSLQET	ubiquitination	[1]
326	LQETYEAKRNEFLGE	ubiquitination	[2]
336	EFLGELQKKEEEMRQ	ubiquitination	[3]
361	AELKEAEKELHEKFD	acetylation	[4]
418	QSGAQQTKKDKDKKN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. 

Sequence Annotation

 NP_BIND 48 55 GTP (By similarity).
 NP_BIND 184 192 GTP (By similarity).
 BINDING 103 103 GTP; via amide nitrogen (By similarity).
 BINDING 238 238 GTP; via amide nitrogen and carbonyl
 BINDING 253 253 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Cell junction; Cell projection; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Nucleotide-binding; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 429 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0001725; C:stress fiber; IDA:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051291; P:protein heterooligomerization; IDA:UniProtKB. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS