UniProt Accession

 HELT_MOUSE; Q7TS99 

Genbank Protein ID

 AB120968; AB098077; DQ294234; BC103599; BC103600; BC103601 

Genbank Nucleotide ID

 BAD11127.1; BAC77659.1; ABB96784.1; AAI03600.1; AAI03601.1; AAI03602.1 

Protein Name

 Hairy and enhancer of split-related protein HELT 

Protein Synonyms/Alias

 HES/HEY-like transcription factor; Protein Hes-like; Protein megane 

Gene Name

 Helt 

Gene Synonyms/Alias

 Hesl; Mgn 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
48	LAKQSSGKLEKAEIL	acetylation	[1]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons. 

Sequence Annotation

 DOMAIN 10 65 bHLH.
 DOMAIN 86 121 Orange.  

Keyword

 Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 240 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0007417; P:central nervous system development; IMP:MGI.
 GO:0021858; P:GABAergic neuron differentiation in basal ganglia; IMP:MGI.
 GO:0010467; P:gene expression; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0010259; P:multicellular organismal aging; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0001967; P:suckling behavior; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom.
 IPR003650; Orange. 

Pfam

 PF07527; Hairy_orange
 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH
 PS51054; ORANGE 

PRINTS