UniProt Accession

 FRDA_YEAST; Q07540; D6VRN0 

Genbank Protein ID

 Z74168; AY558160; BK006938 

Genbank Nucleotide ID

 CAA98688.1; AAS56486.1; DAA11740.1 

Protein Name

 Frataxin homolog, mitochondrial 

Protein Synonyms/Alias

 Frataxin homolog intermediate form 

Gene Name

 YFH1 

Gene Synonyms/Alias

 YDL120W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
168	ILTEEVEKAISKSQ*	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Heme biosynthesis; Ion transport; Iron; Iron storage; Iron transport; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 174 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0008199; F:ferric iron binding; IEA:InterPro.
 GO:0008198; F:ferrous iron binding; IDA:SGD.
 GO:0004322; F:ferroxidase activity; IDA:SGD.
 GO:0034986; F:iron chaperone activity; IDA:SGD.
 GO:0006879; P:cellular iron ion homeostasis; IMP:SGD.
 GO:0006749; P:glutathione metabolic process; IMP:SGD.
 GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0016226; P:iron-sulfur cluster assembly; IMP:SGD.
 GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IMP:UniProtKB.
 GO:0010040; P:response to iron(II) ion; IMP:UniProtKB.
 GO:0006979; P:response to oxidative stress; IMP:UniProtKB. 

Interpro

 IPR017789; Frataxin.
 IPR002908; Frataxin/CyaY.
 IPR020895; Frataxin_CS. 

Pfam

 PF01491; Frataxin_Cyay 

SMART

  

PROSITE

 PS01344; FRATAXIN_1
 PS50810; FRATAXIN_2 

PRINTS