UniProt Accession

 NOP4_YEAST; P37838; D6W3X0 

Genbank Protein ID

 U02598; X76245; U44030; BK006949 

Genbank Nucleotide ID

 AAA20590.1; CAA53824.1; AAB68177.1; DAA11386.1 

Protein Name

 Nucleolar protein 4 

Protein Synonyms/Alias

 Nucleolar protein NOP77 

Gene Name

 NOP4 

Gene Synonyms/Alias

 NOP77; YPL043W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
144	DGEDSMLKGKPKLII	acetylation	[1]
312	SLAPHFSKFGSVKYA	acetylation	[2]
325	YALPVIDKSTGLAKG	ubiquitination	[3]

Reference

 [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for 60S ribosomal subunit synthesis. Probably involved in the processing of 27S rRNA to produce mature 25S rRNA. 

Sequence Annotation

 DOMAIN 26 103 RRM 1.
 DOMAIN 147 225 RRM 2.
 DOMAIN 290 383 RRM 3.
 DOMAIN 462 612 RRM 4.
 MOD_RES 247 247 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 685 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; TAS:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:SGD.
 GO:0006364; P:rRNA processing; TAS:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS