UniProt Accession

 ADRM1_RAT; Q9JMB5; Q6P795 

Genbank Protein ID

 AB032742; BC061773 

Genbank Nucleotide ID

 BAA92929.1; AAH61773.1 

Protein Name

 Proteasomal ubiquitin receptor ADRM1 

Protein Synonyms/Alias

 110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Rpn13 homolog 

Gene Name

 Adrm1 

Gene Synonyms/Alias

 Gp110 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
21	GSRGSSTKYLVEFRA	ubiquitination	[1]
34	RAGKMSLKGTTVTPD	ubiquitination	[1]
397	KEGDTKDKKDEEEDM	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions as a proteasomal ubiquitin receptor. Recruits and activates the deubiquitinating enzyme UCHL5 at the 26S proteasome (By similarity). 

Sequence Annotation

 DOMAIN 22 130 PH.
 REGION 2 132 Interaction with PSMD1 (By similarity).
 REGION 362 407 Interaction with UCHL5 (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 211 211 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 217 217 Phosphothreonine (By similarity).
 CROSSLNK 34 34 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000502; C:proteasome complex; ISS:UniProtKB.
 GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
 GO:0043248; P:proteasome assembly; ISS:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR006773; 26S_Psome_Ubiquitin-recp_Rpn13. 

Pfam

 PF04683; Proteasom_Rpn13 

SMART

  

PROSITE

 PS50003; PH_DOMAIN 

PRINTS