UniProt Accession

 GP1BA_HUMAN; P07359; Q14441; Q16469; Q8N1F3; Q8NG39; Q9HDC7; Q9UEK1; Q9UQS4 

Genbank Protein ID

 J02940; M22403; AB038516; AB086948; AF395009; BC027955; D85894; S34436; S34439; L39103 

Genbank Nucleotide ID

 AAA52595.1; AAA52596.1; BAB12038.1; BAC10305.1; AAK71325.1; AAH27955.1; BAA12911.1; AAB22152.1; AAB22153.1; AAA69491.1 

Protein Name

 Platelet glycoprotein Ib alpha chain 

Protein Synonyms/Alias

 GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; CD42b; Glycocalicin 

Gene Name

 GP1BA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
304	EEDTEGDKVRATRTV	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. 

Sequence Annotation

 DOMAIN 17 47 LRRNT.
 REPEAT 48 68 LRR 1.
 REPEAT 72 93 LRR 2.
 REPEAT 94 115 LRR 3.
 REPEAT 117 137 LRR 4.
 REPEAT 141 162 LRR 5.
 REPEAT 165 186 LRR 6.
 REPEAT 189 210 LRR 7.
 DOMAIN 221 282 LRRCT.
 MOD_RES 292 292 Sulfotyrosine.
 MOD_RES 294 294 Sulfotyrosine.
 MOD_RES 295 295 Sulfotyrosine.
 MOD_RES 603 603 Phosphoserine.
 MOD_RES 606 606 Phosphoserine.
 CARBOHYD 37 37 N-linked (GlcNAc...).
 CARBOHYD 175 175 N-linked (GlcNAc...).
 CARBOHYD 308 308 O-linked (GalNAc...).
 DISULFID 20 33
 DISULFID 225 264
 DISULFID 227 280
 DISULFID 500 500 Interchain (with C-147 in GP1BB).
 DISULFID 501 501 Interchain (with C-147 in GP1BB).  

Keyword

 3D-structure; Bernard Soulier syndrome; Blood coagulation; Cell adhesion; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Leucine-rich repeat; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Sulfation; Transmembrane; Transmembrane helix; von Willebrand disease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 626 AA 

Protein Sequence

Gene Ontology

 GO:0031362; C:anchored to external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015057; F:thrombin receptor activity; TAS:UniProtKB.
 GO:0007597; P:blood coagulation, intrinsic pathway; TAS:Reactome.
 GO:0007155; P:cell adhesion; IDA:MGI.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0042730; P:fibrinolysis; IDA:UniProtKB.
 GO:0030168; P:platelet activation; TAS:UniProtKB. 

Interpro

 IPR000483; Cys-rich_flank_reg_C.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 

Pfam

 PF00560; LRR_1
 PF01462; LRRNT 

SMART

 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 

PROSITE

 PS51450; LRR 

PRINTS