CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038767
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat and HMG-box DNA-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 Wdhd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
664IREHCKGKSDHYWVVacetylation[1, 2]
958VIKPLTPKPRSKQASacetylation[3]
1109LNLPANQKLSAFAFKacetylation[1]
1116KLSAFAFKQE*****acetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1118 AA 
Protein Sequence
MPATQKPMRY GHTEGHTEVC FDDSGSYIVT CGSDGDVRMW EDLDDDDPKS VNVGEKAFSC 60
ALKNGKLVTA VSNNTVQVYT FPEGVPDGIL TRFTTNANHV VFNGAGNKIA AGSSDFLVKV 120
VDVMDNSQQQ TFRGHDAPVL SLSFDPKDIF LASASCDGTV RVWNISDQTC AVSWPVLQKS 180
NDVVNAKSIC RLAWQPKAGK LLAVPVEKSV KLYRRETWSN PFDLSDSSIS QTLNIVTWSP 240
CGQYLAAGAI NGLIVVWNVE TKDCMERVKH EKGYAICGLA WHPTCSRICY TDVEGNLGVL 300
ENVCDLSGKV SSNKVSSRVE KDYNDLFDGD DTSSAGDFLN DNAVEIPSFS KGIINEDDDN 360
DDIMLAADHD LGDDENSVDV TMLKADLSHK EEGDDDQARS IHNLPLIRPQ RPFYDGPMPT 420
PRQKPFQSSS TPLHLSHRFM VWNSVGIIRC YNDDQDSAID VEFHDTSIHH ATHLLNAFNY 480
TMGTLSHEAI LLACESADEL ASKLHCLHFS SWDSSKEWMV DMPQNEDIEA ICLGLGWAAA 540
ATTALLLRLF TIGGVQKEVF CLPGPVVSMA GHGEQLCIVY HRGTGFDGDQ CLGVQLLELG 600
RKKNQVLHGD PLPLTRKSYL TWLGFSAEGT PCYVDSEGCV RMLNRGLGNT WTPVCNIREH 660
CKGKSDHYWV VGIHENPQQL RCIPCKGSRF PPTLPRPAVA ILSFKLPYCQ TSTEKGQMEE 720
QFWHSVLFHN YLDYLAKNGY DYEESIKNQA VKEQQELLMK MLALSCKLER EFRCVELADL 780
MTQNAVHLAI KYASRSRKLI LAQKLSELAA EKAAELAETQ SEEEKEEDFR EKLNAGYSHT 840
TTEWSRPRVR SQVEDAEDRE DTVSEEKPES HNHGQNLFQS ANSSDTPALK SGAVFSSSQG 900
WVNPFKVVVS SKEPAVSANS TRSANILDSM NKSSRKSTSL NRMENNEKSP VIKPLTPKPR 960
SKQASAASYF QKRTPQADKT EEVKENPKSS SSDAPAVCLQ NSENQRPKTG FQMWLEENRS 1020
QILSDNPDIS DETDIIKEGM IRFRVLSAEE RKAWTNKAKG ETASDGAEAK KRKRVVSEIC 1080
ETENQEETVK ENLDLSKKQK ALNLPANQKL SAFAFKQE 1118 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0070063; F:RNA polymerase binding; IDA:MGI.
 GO:0070829; P:heterochromatin maintenance; IMP:MGI.
 GO:0033044; P:regulation of chromosome organization; IMP:MGI.
 GO:0006396; P:RNA processing; IMP:MGI. 
Interpro
 IPR022100; DUF3639.
 IPR009071; HMG_box_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF12341; DUF3639
 PF00505; HMG_box
 PF00400; WD40 
SMART
 SM00398; HMG
 SM00320; WD40 
PROSITE
 PS50118; HMG_BOX_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS