CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calmodulin-regulated spectrin-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 CAMSAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49NLQWICAKAYGRDNIubiquitination[1, 2]
1352KARRELIKQEYLRRKubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in the regulation of cell morphology and cytoskeletal organization. 
Sequence Annotation
 DOMAIN 183 328 CH.
 DOMAIN 1463 1597 CKK.
 MOD_RES 217 217 Phosphoserine.
 MOD_RES 371 371 Phosphoserine.
 MOD_RES 375 375 Phosphoserine.
 MOD_RES 512 512 Phosphothreonine.
 MOD_RES 575 575 Phosphoserine.
 MOD_RES 589 589 Phosphoserine.
 MOD_RES 722 722 Phosphoserine.
 MOD_RES 1537 1537 Phosphotyrosine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1602 AA 
Protein Sequence
MVDASGRAAA EGWRKMEAPP DGAADLVPLD RYDAARAKIA ANLQWICAKA YGRDNIPEDL 60
RDPFYVDQYE QEHIKPPVIK LLLSSELYCR VCSLILKGDQ VAALQGHQSV IQALSRKGIY 120
VMESDDTPVT ESDLSRAPIK MSAHMAMVDA LMMAYTVEMI SIEKVVASVK RFSTFSASKE 180
LPYDLEDAMV FWINKVNLKM REITEKEVKL KQQLLESPAH QKSPSKWYWK LVPVRYRREH 240
LSARQSPYFP LLEDLMRDGS DGAALLAVIH YYCPEQMKLD DICLKEVTSM ADSLYNIRLL 300
REFSNEYLNK CFYLTLEDML YAPLVLKPNV MVFIAELFWW FENVKPDFVQ PRDVQELKDA 360
KTVLHQKSSR PPVPISNATK RSFLGSPAAG TLAELQPPVQ LPAEGCHRHY LHPEEPEYLG 420
KGTAAFSPSH PLLPLRQKQQ KSIQGEDIPD QRHRSNSLTR VDGQPRGAAI AWPEKKTRPA 480
SQPTPFALHH AASCEVDPSS GDSISLARSI SKDSLASNIV NLTPQNQPHP TATKSHGKSL 540
LSNVSIEDEE EELVAIVRAD VVPQQADPEF PRASPRALGL TANARSPQGQ LDTSESKPDS 600
FFLEPLMPAV LKPAKEKQVI TKEDERGEGR PRSIVSRRPS EGPQPLVRRK MTGSRDLNRT 660
FTPIPCSEFP MGIDPTETGP LSVETAGEVC GGPLALGGFD PFPQGPSTDG FFLHVGRADE 720
DTEGRLYVSC SKSPNSHDSE PWTLLRQDSD SDVVDIEEAE HDFMGEAHPV VFSRYIGEEE 780
SAKLQEDMKV KEHEDKDDAS GRSSPCLSTA SQMSSVSMAS GSVKMTSFAE RKLQRLNSCE 840
TKSSTSSSQK TTPDASESCP APLTTWRQKR EQSPSQHGKD PASLLASELV QLHMQLEEKR 900
RAIEAQKKKM EALSARQRLK LGKAAFLHVV KKGKAEAAPP LRPEHFAKEY SQHNGEDCGD 960
AVSKTEDFLV KEEQREELLH EPQDVDKESL AFAQQHKAKD PVALHELERN KVISAALLED 1020
TVGEVVDVNE CDLSIEKLNE TISTLQQAIL KISQQQEQLL MKSPTVPVPG SKNNSQDHKV 1080
KAPVHFVEPL SPTGVAGHRK APRLGQGRNS RSGRPAELKV PKDRPQGSSR SKTPTPSVET 1140
LPHLRPFPAS SHPRTPTDPG LDSALEPSGD PHGKCLFDSY RLHDESNQRT LTLSSSKDAN 1200
ILSEQMSLKE VLDASVKEVG SSSSDVSGKE SVPVEEPLRS RASLIEVDLS DLKAPDEDGE 1260
LVSLDGSADL VSEGDQKPGV GFFFKDEQKA EDELAKKRAA FLLKQQRKAE EARVRKQQLE 1320
AEVELKRDEA RRKAEEDRVR KEEEKARREL IKQEYLRRKQ QQILEEQGLG KPKSKPKKPR 1380
PKSVHREESC SDSGTKCSST PDNLSRTQSG SSLSLASAAT TEPESVHSGG TPSQRVESME 1440
ALPILSRNPS RSTDRDWETA SAASSLASVA EYTGPKLFKE PSSKSNKPII HNAISHCCLA 1500
GKVNEPHKNS ILEELEKCDA NHYIILFRDA GCQFRALYCY YPDTEEIYKL TGTGPKNITK 1560
KMIDKLYKYS SDRKQFNLIP AKTMSVSVDA LTIHNHLWQP KRPAVPKKAQ TRK 1613 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. 
Interpro
 IPR022613; CAMSAP_CH.
 IPR001715; CH-domain.
 IPR014797; CKK_domain.
 IPR011033; PRC_barrel-like. 
Pfam
 PF11971; CAMSAP_CH
 PF08683; CAMSAP_CKK 
SMART
 SM01051; CAMSAP_CKK 
PROSITE
 PS50021; CH
 PS51508; CKK 
PRINTS