CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
 ATP-binding cassette, sub-family A (ABC1), member 2 
Gene Name
 Abca2 
Gene Synonyms/Alias
 mCG_18727 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1335ENSEADVKESRKDVLubiquitination[1]
1339ADVKESRKDVLPGAEubiquitination[1]
2025QRLPVSTKPVEDDVDubiquitination[1]
2177LEKLELTKYADKPAGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2433 AA 
Protein Sequence
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS VKEAFYTAAP 60
LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH RVVEEGNLFD PVRPSLGSEL 120
EALRQRLEAL SSGPGTWESH SARPAVSSFS LDSVARDQRE LWRFLMQNLS LPNSTAQALL 180
AARVDPSEVY RLLFGPLPDL DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA 240
PGSGELGRIL TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG 300
FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA CAGQASAPQA 360
SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG QCSAFVQLWA GLQPILCGNN 420
RTIEPEALRR GNMSSLGFTS KEQRNLGLLV HLMTSNPKIL YAPVGSEADR VILKANETFA 480
FVGNVTHYAQ VWLNISTEIR SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL 540
RQDFSLPNGT ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV 600
TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG RFYFLYGFVW 660
IQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF VIEHMMPLCM VISWVYSVAM 720
TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA WFITGFVQLS ISVTALTAIL KYGQVLMHSH 780
VLIIWLFLAV YAVATIMFCF LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK 840
ITAFEKCIAS LMSTTAFGLG SKYFALYEVA GVGIQWHTFS QSPVEGDDFN LLLAVTMLMV 900
DTVVYGVLTW YIEAVHPGMY GLPRPWYFPL QKSYWLGSGR TEAWEWSWPW AHTPRLSVME 960
EDQACAMESR HFEETRGMEE EPTHLPLVVC VDKLTKVYKN DKKMALNKLS LNLYENQVVS 1020
FLGHNGAGKT TTMSILTGLF PPTSGSATIY GHDIRTEMDE IRKNLGMCPQ HNVLFDRLTV 1080
EEHLWFYSRL KSMAQEEIRK ETDKMIEDLE LSNKRHSLVQ TLSGGMKRKL SVAIAFVGGS 1140
RAIILDEPTA GVDPYARRAI WDLILKYKPG RTILLSTHHM DEADLLGDRI AIISHGKLKC 1200
CGSPLFLKGA YGDGYRLTLV KQPAEPGTSQ EPGLASSPSG CPRLSSCSEP QVSQFIRKHV 1260
ASSLLVSDTS TELSYILPSE AVKKGAFERL FQQLEHSLDA LHLSSFGLMD TTLEEVFLKV 1320
SEEDQSLENS EADVKESRKD VLPGAEGLTA VGGQAGNLAR CSELAQSQAS LQSASSVGSA 1380
RGEEGTGYSD GYGDYRPLFD NLQDPDNVSL QEAEMEALAQ VGQGSRKLEG WWLKMRQFHG 1440
LLVKRFHCAR RNSKALCSQI LLPAFFVCVA MTVALSVPEI GDLPPLVLSP SQYHNYTQPR 1500
GNFIPYANEE RQEYRLRLSP DASPQQLVST FRLPSGVGAT CVLKSPANGS LGPMLNLSSG 1560
ESRLLAARFF DSMCLESFTQ GLPLSNFVPP PPSPAPSDSP VSPDEDSLQA WNMSLPPTAG 1620
PETWTSAPSL PRLVHEPVRC TCSAQGTGFS CPSSVGGHPP QMRVVTGDIL TDITGHNVSE 1680
YLLFTSDRFR LHRYGAITFG NVQKSIPASF GARVPPMVRK IAVRRVAQVL YNNKGYHSMP 1740
TYLNSLNNAI LRANLPKSKG NPAAYGITVT NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV 1800
AMSFVPASFV VFLVAEKSTK AKHLQFVSGC NPVIYWLANY VWDMLNYLVP ATCCVIILFV 1860
FDLPAYTSPT NFPAVLSLFL LYGWSITPIM YPASFWFEVP SSAYVFLIVI NLFIGITATV 1920
ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN YNLGHGLMEM AYNEYINEYY AKIGQFDKMK 1980
SPFEWDIVTR GLVAMTVEGF VGFFLTIMCQ YNFLRQPQRL PVSTKPVEDD VDVASERQRV 2040
LRGDADNDMV KIENLTKVYK SRKIGRILAV DRLCLGVRPG ECFGLLGVNG AGKTSTFKML 2100
TGDESTTGGE AFVNGHSVLK DLLQVQQSLG YCPQFDALFD ELTAREHLQL YTRLRGIPWK 2160
DEAQVVKWAL EKLELTKYAD KPAGTYSGGN KRKLSTAIAL IGYPAFIFLD EPTTGMDPKA 2220
RRFLWNLILD LIKTGRSVVL TSHSMEECEA LCTRLAIMVN GRLRCLGSIQ HLKNRFGDGY 2280
MITVRTKSSQ NVKDVVRFFN RNFPEAMLKE RHHTKVQYQL KSEHISLAQV FSKMEQVVGV 2340
LGIEDYSVSQ TTLDNVFVNF AKKQSDNVEQ QEAEPSSLPS PLGLLSLLRP RPAPTELRAL 2400
VADEPEDLDT EDEGLISFEE ERAQLSFNTD TLC 2433 
Gene Ontology
 GO:0005768; C:endosome; IEA:Compara.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0032383; P:regulation of intracellular cholesterol transport; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048545; P:response to steroid hormone stimulus; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS