UniProt Accession

 Q543K9_MOUSE; Q543K9 

Genbank Protein ID

 AC136376; AK049817; AK153451; CT010254 

Genbank Nucleotide ID

 BAC33932.1; BAE32005.1; CAJ18462.1 

Protein Name

 Purine nucleoside phosphorylase 

Protein Synonyms/Alias

 Inosine-guanosine phosphorylase 

Gene Name

 Pnp 

Gene Synonyms/Alias

 Pnp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
95	YEGYSLSKVTFPVRV	ubiquitination	[1]
173	YDRDMRQKAFSAWKQ	ubiquitination	[1]
179	QKAFSAWKQMGEQRK	ubiquitination	[1]
186	KQMGEQRKLQEGTYV	ubiquitination	[1]
210	VAESRLLKMLGADAV	ubiquitination	[1]
254	MDYENLEKANHMEVL	ubiquitination	[1]
265	MEVLDAGKAAAQTLE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:MGI.
 GO:0006161; P:deoxyguanosine catabolic process; IMP:MGI.
 GO:0006149; P:deoxyinosine catabolic process; IMP:MGI.
 GO:0046070; P:dGTP metabolic process; IMP:MGI.
 GO:0006183; P:GTP biosynthetic process; IMP:MGI.
 GO:0046115; P:guanosine catabolic process; IMP:MGI.
 GO:0006148; P:inosine catabolic process; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IMP:MGI.
 GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.
 GO:0045739; P:positive regulation of DNA repair; IMP:MGI.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI.
 GO:0042102; P:positive regulation of T cell proliferation; IMP:MGI.
 GO:0010332; P:response to gamma radiation; IMP:MGI.
 GO:0034418; P:urate biosynthetic process; IMP:MGI. 

Interpro

 IPR000845; Nucleoside_phosphorylase_d.
 IPR001369; PNP/MTAP.
 IPR011270; Pur_Nuc_Pase_Ino/Guo-sp.
 IPR011268; Purine_phosphorylase.
 IPR018099; Purine_phosphorylase-2_CS. 

Pfam

 PF01048; PNP_UDP_1 

SMART

  

PROSITE

 PS01240; PNP_MTAP_2 

PRINTS