CPLM-001401

Genbank Nucleotide ID

Protein Synonyms/Alias

Contraception-associated protein 1; Protein CAP1; Fertility protein SP22; Parkinson disease protein 7 homolog

Rattus norvegicus (Rat)

Position	Peptide	Type	References
93	ALVKEILKEQENRKG	acetylation	[1]
130	VTSHPLAKDKMMNGS	acetylation	[1]
132	SHPLAKDKMMNGSHY	acetylation	[1]
148	YSESRVEKDGLILTS	acetylation	[1]
188	VKAPLVLKD******	acetylation	[1]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity).

ACT_SITE 106 106 By similarity.
ACT_SITE 126 126 By similarity.
MOD_RES 67 67 Phosphotyrosine (By similarity).
MOD_RES 106 106 Cysteine sulfinic acid (-SO2H) (By
CROSSLNK 130 130 Glycyl lysine isopeptide (Lys-Gly)

Autophagy; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Fertilization; Hydrolase; Inflammatory response; Isopeptide bond; Mitochondrion; Nucleus; Oxidation; Phosphoprotein; Protease; Reference proteome; RNA-binding; Stress response; Tumor suppressor; Ubl conjugation; Zymogen.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030424; C:axon; IDA:RGD.
GO:0005829; C:cytosol; IDA:RGD.
GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003729; F:mRNA binding; ISS:UniProtKB.
GO:0008233; F:peptidase activity; ISS:UniProtKB.
GO:0004601; F:peroxidase activity; ISS:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
GO:0032091; P:negative regulation of protein binding; ISS:UniProtKB.
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; ISS:UniProtKB.
GO:0050821; P:protein stabilization; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
GO:0043523; P:regulation of neuron apoptotic process; ISS:UniProtKB.
GO:0042493; P:response to drug; IEP:RGD.
GO:0007338; P:single fertilization; IEA:UniProtKB-KW.

IPR006287; DJ1.
IPR002818; ThiJ/PfpI.