CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014298
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 1G 
Protein Synonyms/Alias
 Fibroblast growth factor-inducible protein 13; FIN13; Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma 
Gene Name
 Ppm1g 
Gene Synonyms/Alias
 Fin13; Ppm1c 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
247SCSSASDKLPRVAKSubiquitination[1]
336VVALIRGKQLIVANAubiquitination[1]
380RIKNAGGKVTMDGRVacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May be involved in regulation of cell cycle. 
Sequence Annotation
 METAL 60 60 Manganese 1 (By similarity).
 METAL 60 60 Manganese 2 (By similarity).
 METAL 61 61 Manganese 1; via carbonyl oxygen (By
 METAL 438 438 Manganese 2 (By similarity).
 METAL 493 493 Manganese 2 (By similarity).
 MOD_RES 380 380 N6-acetyllysine (By similarity).
 MOD_RES 524 524 Phosphoserine (By similarity).  
Keyword
 Acetylation; Cell cycle; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD NETAMFSVYD 60
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA IDAKLTTEEV IKELAQIAGR 120
PTEDEDDKDK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCQKVPPH TKSGIGTGDE 180
PGPQGLNGEA GPEDPSRETP SQENGPTAKG HTGFSSNSEH GTEAGQISEP GTATGEAGPS 240
CSSASDKLPR VAKSKFFEDS EDESDEVEEE EDDSEECSED EDGYSSEEAE NEEDEDDTEE 300
AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV SEAGKALDMS 360
YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH FYKRNKNLPP QEQMISALPD 420
IKVLTLTDDH EFMVIACDGI WNVMSSQEVV DFIQSKISQR DENGELRLLS SIVEELLDQC 480
LAPDTSGDGT GCDNMTCIII CFKPRNTVEL QAESGKRKLE EALSTEGAED TGNSDKKKAK 540
RD 542 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IDA:MGI.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IDA:MGI.
 GO:0035970; P:peptidyl-threonine dephosphorylation; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IDA:MGI. 
Interpro
 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 
Pfam
 PF00481; PP2C 
SMART
 SM00331; PP2C_SIG
 SM00332; PP2Cc 
PROSITE
 PS01032; PP2C 
PRINTS