CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004422
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukosialin 
Protein Synonyms/Alias
 Galactoglycoprotein; GALGP; Leukocyte sialoglycoprotein; Sialophorin; CD43 
Gene Name
 SPN 
Gene Synonyms/Alias
 CD43 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
362SLAMEELKSGSGPSLubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). 
Sequence Annotation
 MOD_RES 291 291 Phosphoserine.
 MOD_RES 351 351 Phosphoserine.
 MOD_RES 355 355 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 CARBOHYD 21 21 O-linked (GalNAc...).
 CARBOHYD 22 22 O-linked (GalNAc...).
 CARBOHYD 26 26 O-linked (GalNAc...).
 CARBOHYD 28 28 O-linked (GalNAc...).
 CARBOHYD 29 29 O-linked (GalNAc...).
 CARBOHYD 35 35 O-linked (GalNAc...).
 CARBOHYD 36 36 O-linked (GalNAc...).
 CARBOHYD 37 37 O-linked (GalNAc...).
 CARBOHYD 41 41 O-linked (GalNAc...).
 CARBOHYD 42 42 O-linked (GalNAc...).
 CARBOHYD 46 46 O-linked (GalNAc...).
 CARBOHYD 47 47 O-linked (GalNAc...).
 CARBOHYD 48 48 O-linked (GalNAc...).
 CARBOHYD 50 50 O-linked (GalNAc...).
 CARBOHYD 58 58 O-linked (GalNAc...).
 CARBOHYD 69 69 O-linked (GalNAc...).
 CARBOHYD 99 99 O-linked (GalNAc...).
 CARBOHYD 103 103 O-linked (GalNAc...).
 CARBOHYD 109 109 O-linked (GalNAc...).
 CARBOHYD 113 113 O-linked (GalNAc...).
 CARBOHYD 114 114 O-linked (GalNAc...).
 CARBOHYD 136 136 O-linked (GalNAc...).
 CARBOHYD 137 137 O-linked (GalNAc...).
 CARBOHYD 173 173 O-linked (GalNAc...).
 CARBOHYD 178 178 O-linked (GalNAc...).
 CARBOHYD 239 239 N-linked (GlcNAc...).  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD 60
QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI 120
TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK 180
GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA 240
STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 300
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE 360
LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP 400 
Gene Ontology
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0001931; C:uropod; IEA:Compara.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:Compara.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0006935; P:chemotaxis; TAS:ProtInc.
 GO:0042742; P:defense response to bacterium; IDA:MGI.
 GO:0007163; P:establishment or maintenance of cell polarity; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0007162; P:negative regulation of cell adhesion; TAS:ProtInc.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0001808; P:negative regulation of type IV hypersensitivity; IEA:Compara.
 GO:0045060; P:negative thymic T cell selection; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara.
 GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IDA:MGI.
 GO:0050688; P:regulation of defense response to virus; IEA:Compara.
 GO:0001562; P:response to protozoan; IEA:Compara.
 GO:0031295; P:T cell costimulation; IEA:Compara. 
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