UniProt Accession

 GLRX4_ECOLI; P0AC69; P37010; P77424 

Genbank Protein ID

 U00096; AP009048; L01622 

Genbank Nucleotide ID

 AAC74726.1; BAA15420.1; AAC37010.1 

Protein Name

 Glutaredoxin-4 

Protein Synonyms/Alias

 Grx4; Monothiol glutaredoxin 

Gene Name

 grxD 

Gene Synonyms/Alias

 ydhD; b1654; JW1646 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
7	*MSTTIEKIQRQIAE	acetylation	[1, 2, 3]
22	NPILLYMKGSPKLPS	acetylation	[3]
26	LYMKGSPKLPSCGFS	acetylation	[3]
101	GELQQLIKETAAKYK	acetylation	[3]
106	LIKETAAKYKSEEPD	acetylation	[3]

Reference

 [1] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable). 

Sequence Annotation

 DOMAIN 5 107 Glutaredoxin.
 REGION 84 85 Glutathione binding.
 METAL 30 30 Iron-sulfur (2Fe-2S); shared with dimeric
 BINDING 22 22 Glutathione.
 BINDING 59 59 Glutathione.
 BINDING 71 71 Glutathione; via amide nitrogen and  

Keyword

 2Fe-2S; 3D-structure; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:EcoCyc.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 

Interpro

 IPR002109; Glutaredoxin.
 IPR014434; Monothiol_GRX.
 IPR004480; Monothiol_GRX-rel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS51354; GLUTAREDOXIN_2 

PRINTS