UniProt Accession

 ZDHC2_HUMAN; Q9UIJ5; D3DSP5 

Genbank Protein ID

 AB023584; CH471080; CH471080; BC039253; BC050272 

Genbank Nucleotide ID

 BAA88923.1; EAW63824.1; EAW63825.1; AAH39253.1; AAH50272.1 

Protein Name

 Palmitoyltransferase ZDHHC2 

Protein Synonyms/Alias

 Reduced expression associated with metastasis protein; Ream; Reduced expression in cancer protein; Rec; Zinc finger DHHC domain-containing protein 2; DHHC-2; Zinc finger protein 372 

Gene Name

 ZDHHC2 

Gene Synonyms/Alias

 REAM; REC; ZNF372 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	EVLRRAAKDLPIYTR	ubiquitination	[1]
257	VFRHGTDKNGFSLGF	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity). 

Sequence Annotation

 ZN_FING 127 177 DHHC-type.  

Keyword

 Acyltransferase; Complete proteome; Membrane; Metal-binding; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016409; F:palmitoyltransferase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0018345; P:protein palmitoylation; IEA:Compara. 

Interpro

 IPR001594; Znf_DHHC_palmitoyltrfase. 

Pfam

 PF01529; zf-DHHC 

SMART

  

PROSITE

 PS50216; ZF_DHHC 

PRINTS