CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044594
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA repair protein RAD51 homolog 3 
Protein Synonyms/Alias
  
Gene Name
 RAD51C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26LSPAVRVKLVSAGFQubiquitination[1]
42AEELLEVKPSELSKEubiquitination[1]
48VKPSELSKEVGISKAubiquitination[1]
54SKEVGISKAEALETLubiquitination[1, 2, 3, 4]
72RRECLTNKPRYAGTSubiquitination[3, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET 60
LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT 120
TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL 180
QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI 240
VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 300
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKVSII 346 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
 GO:0006259; P:DNA metabolic process; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013632; DNA_recomb/repair_Rad51_C.
 IPR016467; DNA_recomb/repair_RecA-like.
 IPR020588; DNA_recomb_RecA/RadB_ATP-bd.
 IPR027417; P-loop_NTPase. 
Pfam
 PF08423; Rad51 
SMART
 SM00382; AAA 
PROSITE
 PS50162; RECA_2 
PRINTS