CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002946
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospho-N-acetylmuramoyl-pentapeptide-transferase 
Protein Synonyms/Alias
 UDP-MurNAc-pentapeptide phosphotransferase 
Gene Name
 mraY 
Gene Synonyms/Alias
 murX; b0087; JW0085 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
50RMIAHLQKLSFGQVVacetylation[1]
331IHHHYELKGWPEPRVacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan. 
Sequence Annotation
  
Keyword
 Cell cycle; Cell division; Cell inner membrane; Cell membrane; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Magnesium; Manganese; Membrane; Peptidoglycan synthesis; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MLVWLAEHLV KYYSGFNVFS YLTFRAIVSL LTALFISLWM GPRMIAHLQK LSFGQVVRND 60
GPESHFSKRG TPTMGGIMIL TAIVISVLLW AYPSNPYVWC VLVVLVGYGV IGFVDDYRKV 120
VRKDTKGLIA RWKYFWMSVI ALGVAFALYL AGKDTPATQL VVPFFKDVMP QLGLFYILLA 180
YFVIVGTGNA VNLTDGLDGL AIMPTVFVAG GFALVAWATG NMNFASYLHI PYLRHAGELV 240
IVCTAIVGAG LGFLWFNTYP AQVFMGDVGS LALGGALGII AVLLRQEFLL VIMGGVFVVE 300
TLSVILQVGS FKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISLMLV LIGLATLKVR 360 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IDA:EcoliWiki.
 GO:0051992; F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity; IEA:EC.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR000715; Glycosyl_transferase_4.
 IPR003524; PNAcMuramoyl-5peptid_Trfase.
 IPR018480; PNAcMuramoyl-5peptid_Trfase_CS. 
Pfam
 PF00953; Glycos_transf_4
 PF10555; MraY_sig1 
SMART
  
PROSITE
 PS01347; MRAY_1
 PS01348; MRAY_2 
PRINTS