CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 UBX domain-containing protein 2B 
Protein Synonyms/Alias
 NSFL1 cofactor p37; p97 cofactor p37 
Gene Name
 Ubxn2b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
90KIVNELFKEAREHGAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (By similarity). 
Sequence Annotation
 DOMAIN 141 206 SEP.
 DOMAIN 252 329 UBX.
 MOD_RES 56 56 Phosphoserine (By similarity).
 MOD_RES 59 59 Phosphothreonine (By similarity).
 MOD_RES 231 231 Phosphoserine (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Endoplasmic reticulum; Golgi apparatus; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 331 AA 
Protein Sequence
MAEGGGAEPE EQERRSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST ATAFKSPRTP 60
PLRLYSGDQE YGGLHIAQPP TGKIVNELFK EAREHGAVPL NEATRSSSDD KAKSFTGGGY 120
RLGSSFYKRS EYIYGENQLQ DVQILLRLWS NGFSLDDGEL RPYSDPTNAQ FLESVKRGEI 180
PLELQRLVHG SQVSLDMEDH QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED 240
KSILNAAVLI DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRDFIVQSR PEFATTDFIL 300
VTSFPSKELT DESVTLQDAD ILNTVILQQL K 331 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR012989; SEP_domain.
 IPR001012; UBX. 
Pfam
 PF08059; SEP
 PF00789; UBX 
SMART
 SM00553; SEP
 SM00166; UBX 
PROSITE
 PS51399; SEP
 PS50033; UBX 
PRINTS