CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coxsackievirus and adenovirus receptor 
Protein Synonyms/Alias
 CAR; hCAR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR 
Gene Name
 CXADR 
Gene Synonyms/Alias
 CAR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88DDYYPDLKGRVHFTSacetylation[1]
99HFTSNDLKSGDASINacetylation[1]
121DIGTYQCKVKKAPGVacetylation[1]
271RREEKYEKEVHHDIRubiquitination[2]
315SNMEGYSKTQYNQVPubiquitination[3]
360VMIPAQSKDGSIV**ubiquitination[3]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN. 
Sequence Annotation
 DOMAIN 20 134 Ig-like C2-type 1.
 DOMAIN 141 228 Ig-like C2-type 2.
 MOTIF 360 365 PDZ-binding.
 MOD_RES 293 293 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 323 323 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine.
 LIPID 259 259 S-palmitoyl cysteine (Probable).
 LIPID 260 260 S-palmitoyl cysteine (Probable).
 CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
 CARBOHYD 201 201 N-linked (GlcNAc...) (Potential).
 DISULFID 41 120
 DISULFID 162 212 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 365 AA 
Protein Sequence
MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS 60
PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC 120
KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD 180
SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA 240
GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS 300
SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK 360
DGSIV 365 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
 GO:0005912; C:adherens junction; IDA:UniProtKB.
 GO:0016327; C:apicolateral plasma membrane; IDA:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0044297; C:cell body; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0030175; C:filopodium; ISS:UniProtKB.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0014704; C:intercalated disc; IDA:UniProtKB.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0031594; C:neuromuscular junction; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0071253; F:connexin binding; ISS:UniProtKB.
 GO:0042802; F:identical protein binding; IDA:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.
 GO:0086067; P:AV node cell to bundle of His cell communication; ISS:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0048739; P:cardiac muscle fiber development; ISS:UniProtKB.
 GO:0045216; P:cell-cell junction organization; ISS:UniProtKB.
 GO:0051607; P:defense response to virus; IDA:UniProtKB.
 GO:0010669; P:epithelial structure maintenance; IMP:UniProtKB.
 GO:0008354; P:germ cell migration; ISS:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:UniProtKB.
 GO:0034109; P:homotypic cell-cell adhesion; IDA:UniProtKB.
 GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0030593; P:neutrophil chemotaxis; IMP:UniProtKB.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0070633; P:transepithelial transport; IMP:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS