CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Triple functional domain protein 
Protein Synonyms/Alias
  
Gene Name
 Trio 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
281DLDLEGQKLLQRIQSubiquitination[1]
2099QLTDLLIKPVQRIMKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity). 
Sequence Annotation
 DOMAIN 65 210 CRAL-TRIO.
 REPEAT 218 338 Spectrin 1.
 REPEAT 340 446 Spectrin 2.
 REPEAT 566 672 Spectrin 3.
 REPEAT 673 784 Spectrin 4.
 REPEAT 907 1012 Spectrin 5.
 REPEAT 1138 1244 Spectrin 6.
 DOMAIN 1292 1467 DH 1.
 DOMAIN 1479 1591 PH 1.
 DOMAIN 1656 1721 SH3.
 DOMAIN 1969 2145 DH 2.
 DOMAIN 2157 2271 PH 2.
 DOMAIN 2688 2778 Ig-like C2-type.
 DOMAIN 2799 3053 Protein kinase.
 NP_BIND 2805 2813 ATP (By similarity).
 ACT_SITE 2918 2918 Proton acceptor (By similarity).
 BINDING 2828 2828 ATP (By similarity).
 MOD_RES 2282 2282 Phosphoserine (By similarity).
 MOD_RES 2458 2458 Phosphoserine.
 MOD_RES 2462 2462 Phosphoserine (By similarity).
 DISULFID 2709 2762 By similarity.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disulfide bond; Guanine-nucleotide releasing factor; Immunoglobulin domain; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3102 AA 
Protein Sequence
MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 60
KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 120
KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 180
TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 240
LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 300
NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 360
GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 420
QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 480
EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 540
IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 600
HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 660
RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 720
LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 780
KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 840
LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 900
KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 960
HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1020
EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1080
ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1140
VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1200
QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1260
LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1320
EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1380
QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1440
TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1500
IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1560
RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1620
DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1680
QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1740
SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1800
KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1860
EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 1920
MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKCSSLKRR HYVLQELVET 1980
ERDYVRDLGC VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 2040
PEKLGSLFVK HERRLHMYIV YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 2100
VQRIMKYQLL LKDFLKYSKK ASLDTSELEK AVEVMCIVPK RCNDMMNVGR LQGFDGKIVA 2160
QGKLLLQDTF LVTDQDAGLL PRCKERRVFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 2220
SCLCLEENVE SDPCKFALTS RTGDAVETFV LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 2280
TSPIEYQRNH SGGGGSGSGG SSGGGGGSGG SGASSGGSSS HGSGPSSCSS GPSSSRSRPS 2340
RIPQPVRHHP PMLVSSAASS QAEADKMSGM SAPSPSLPTP SSSLALEASL GQPSRLPLSG 2400
DSEGHERETE PIPKMKVMES PRKAPGSTSG TSQDGNTKDA RGNLGSLPLG KTRPGAVSPL 2460
NSPLSTTFPS PFGKEAFPPS SPLQKGGSFW SSIPASPASR PSSFTFPGDS DSLQRQTHRH 2520
AAPSKDTDRM STCSSASEQS VQSTQSNGSE GSSSSNISTM LVTHEYTAVK EDEINVYQGE 2580
VVQILASNQQ NMFLVFRAAT DQCPAAEGWI PGFVLGHTSA VIMENPDGTL KKSTSWHTAL 2640
RLRKKSEKKD KDGKRDGKLE NGYRKPREGL SNKVSVKLLN PNYIYDVPPE FVIPLSEVTC 2700
ETGETVVFRC RVCGRPKASI TWKGPEHNTL NNDDHYSISY SDIGEATLKI IGVSTEDDGI 2760
YTCIAVNDMG SASSSASLRV LGPGSDGIVV TWKDNFDAFY SEVAELGRGR FAVVKKCDQK 2820
GTKRAVATKF VNKKLMKRDQ VTHELGILQN LQHPLLVSLL DTFETPTSYV LVLEMADQGR 2880
LLDCVVRWGS LTEGKVRAHL GEVLEAVRYL HNCRIAHLDL KPENILVDQS LAKPTIKLAD 2940
FGDAVQLNTT YYIHQLLGNP EFAAPEIILG NPVSLTADTW SVGVLTYVLL SGVSPFLDDS 3000
VEETCLNICR LDFSFPEDYF QGVSQKAKEF VCFLLQEDPA KRPSAALALQ EQWLQAGNGS 3060
GKGTGVLDTS RLTSFIERRK HQNDVRPIRS IKNFLQSRLL PRV 3103 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR001251; CRAL-TRIO_dom.
 IPR000219; DH-domain.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF07679; I-set
 PF00069; Pkinase
 PF00621; RhoGEF
 PF00018; SH3_1
 PF00435; Spectrin 
SMART
 SM00408; IGc2
 SM00233; PH
 SM00325; RhoGEF
 SM00220; S_TKc
 SM00516; SEC14
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS50191; CRAL_TRIO
 PS00741; DH_1
 PS50010; DH_2
 PS50835; IG_LIKE
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50002; SH3 
PRINTS