CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006112
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 2 
Protein Synonyms/Alias
 Actin-like protein ARP2; Actin-like protein 2 
Gene Name
 ARP2 
Gene Synonyms/Alias
 ACT2; YDL029W; D2778 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
52ASVATPLKDIMIGDEubiquitination[1]
117EPPMNPLKNREKMCEubiquitination[1]
252LPDGRTIKVGQERFEubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). 
Sequence Annotation
 NP_BIND 159 161 ATP (By similarity).
 NP_BIND 213 217 ATP (By similarity).
 NP_BIND 304 309 ATP (By similarity).  
Keyword
 Actin-binding; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 391 AA 
Protein Sequence
MDPHNPIVLD QGTGFVKIGR AGENFPDYTF PSIVGRPILR AEERASVATP LKDIMIGDEA 60
SEVRSYLQIS YPMENGIIKN WTDMELLWDY AFFEQMKLPS TSNGKILLTE PPMNPLKNRE 120
KMCEVMFEKY DFGGVYVAIQ AVLALYAQGL SSGVVVDSGD GVTHIVPVYE SVVLSHLTRR 180
LDVAGRDVTR HLIDLLSRRG YAFNRTADFE TVRQIKEKLC YVSYDLDLDT KLARETTALV 240
ESYELPDGRT IKVGQERFEA PECLFQPGLV DVEQPGVGEL LFNTVQSADV DIRSSLYKAI 300
VLSGGSSMYP GLPSRLEKEL KQLWFSRVLH NDPSRLDKFK VRIEDPPRRK HMVFIGGAVL 360
ASIMADKDHM WLSKQEWQES GPSAMTKFGP R 391 
Gene Ontology
 GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
 GO:0005885; C:Arp2/3 protein complex; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005524; F:ATP binding; IDA:SGD.
 GO:0016887; F:ATPase activity; IMP:SGD.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IMP:SGD.
 GO:0030476; P:ascospore wall assembly; IMP:SGD.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0051654; P:establishment of mitochondrion localization; IMP:SGD.
 GO:0000001; P:mitochondrion inheritance; IPI:SGD. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR027306; Arp2. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS01132; ACTINS_ACT_LIKE 
PRINTS
 PR00190; ACTIN.