CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035929
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myocyte-specific enhancer factor 2C 
Protein Synonyms/Alias
  
Gene Name
 MEF2C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64YASTDMDKVLLKYTEubiquitination[1, 2]
68DMDKVLLKYTEYNEPubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 227 AA 
Protein Sequence
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST 60
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KENKGCESPD PDSSYALTPR TEEKYKKINE 120
EFDNMIKSHK IPAVPPPNFE MPVSIPVSSH NSLVYSNPVS SLGNPNLLPL AHPSLQRNSM 180
SPGVTHRPPS AGNTGGLMGG DLTSGAGTSA GNGYGNPRNS PGLLVSP 227 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022102; HJURP_C.
 IPR002100; TF_MADSbox. 
Pfam
 PF12347; HJURP_C
 PF00319; SRF-TF 
SMART
 SM00432; MADS 
PROSITE
 PS00350; MADS_BOX_1
 PS50066; MADS_BOX_2 
PRINTS
 PR00404; MADSDOMAIN.