CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024377
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin, cytoplasmic 2 
Protein Synonyms/Alias
 Gamma-actin; Actin, cytoplasmic 2, N-terminally processed 
Gene Name
 actg1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Xenopus laevis (African clawed frog) 
NCBI Taxa ID
 8355 
Lysine Modification
Position
Peptide
Type
References
84TNWDDMEKIWHHTFYubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine; in Actin, cytoplasmic
 MOD_RES 2 2 N-acetylglutamate; in Actin, cytoplasmic
 MOD_RES 44 44 Methionine sulfoxide (By similarity).
 MOD_RES 73 73 Tele-methylhistidine (By similarity).  
Keyword
 Acetylation; ATP-binding; Cytoplasm; Cytoskeleton; Methylation; Nucleotide-binding; Oxidation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 60
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 120
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 180
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 240
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 300
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 360
EYDESGPSIV HRKCF 375 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 
PRINTS
 PR00190; ACTIN.