CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Septin-4 
Protein Synonyms/Alias
 Brain protein H5; Peanut-like protein 2 
Gene Name
 Sept4 
Gene Synonyms/Alias
 Pnutl2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36SDDAELSKFVKDFPGubiquitination[1]
174TDLYRDRKLLGAEERubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). 
Sequence Annotation
 NP_BIND 151 158 GTP (By similarity).
 NP_BIND 290 298 GTP (By similarity).
 BINDING 185 185 GTP (By similarity).
 BINDING 211 211 GTP; via amide nitrogen (By similarity).
 BINDING 348 348 GTP; via amide nitrogen and carbonyl
 BINDING 363 363 GTP (By similarity).
 MOD_RES 68 68 Phosphoserine.
 MOD_RES 325 325 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MDHSLGWQGN SVPEDGTEAG IKHFLEDSSD DAELSKFVKD FPGSEPYHSA ESKTRVARPQ 60
ILEPRPQSPD LCDDDVEFRG SLWPQPSDSQ QYFSAPAPLS PSSRPRSPWG KLDPYDSSED 120
DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE 180
RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE 240
SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD 300
RKKCKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV 360
RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV 420
KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QRQMKETH 478 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0031514; C:motile cilium; IMP:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; IMP:MGI.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0031398; P:positive regulation of protein ubiquitination; IEA:Compara.
 GO:0048240; P:sperm capacitation; IMP:MGI.
 GO:0030382; P:sperm mitochondrion organization; IMP:MGI. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS