UniProt Accession

 U119B_MOUSE; Q8C4B4; Q14BY8; Q8BRC4; Q922B4 

Genbank Protein ID

 AK045128; AK082614; BC008617; BC112388; BC115529 

Genbank Nucleotide ID

 BAC32235.1; BAC38549.1; AAH08617.1; AAI12389.1; AAI15530.1 

Protein Name

 Protein unc-119 homolog B 

Protein Synonyms/Alias

  

Gene Name

 Unc119b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	PGGLVAGKEEKKKAG	acetylation	[1, 2, 3]
242	NKLVMHNKADYAYNG	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity). 

Sequence Annotation

 BINDING 142 142 Lipid (By similarity).
 MOD_RES 24 24 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Lipid-binding; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
 GO:0008289; F:lipid binding; ISS:UniProtKB.
 GO:0060271; P:cilium morphogenesis; IEA:Compara.
 GO:0042953; P:lipoprotein transport; ISS:UniProtKB. 

Interpro

 IPR008015; GMP_PDE_delta.
 IPR014756; Ig_E-set. 

Pfam

 PF05351; GMP_PDE_delta 

SMART

  

PROSITE

  

PRINTS