CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003944
UniProt Accession
Genbank Protein ID
 M68859; AL645848; AL645477; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; BX000479; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX294443; CR352330; CR382328; AL808024; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL833800; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL844151; BX000479; BX294443; CR352330; CR382328; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL645857; AL645477; AL645848; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL732449; AL645477; AL645848; AL645857; AL672146; AL731776; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; BX294443; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; CR352330; CR382328; CR382328; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR352330; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR382328; AL672146; AL645477; AL645848; AL645857; AL731776; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL806516; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL731776; AL645477; AL645848; AL645857; AL672146; AL732449; AL806516; AL808024; AL833800; AL844151; BX000479; BX294443; CR352330; CR382328; AL844151; AL645477; AL645848; AL645857; AL672146; AL731776; AL732449; AL806516; AL808024; AL833800; BX000479; BX294443; CR352330; CR382328; X58153; M18025; U56724; U15218 
Genbank Nucleotide ID
 AAB02797.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14696.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM14885.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15174.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15349.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM15656.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM16090.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM17038.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20240.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM20576.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22468.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM22949.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM24749.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26197.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAM26796.1; CAA41157.1; AAA37530.1; AAB01216.1; AAA87068.1 
Protein Name
 Dystrophin 
Protein Synonyms/Alias
  
Gene Name
 Dmd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
225VATTYPDKKSILMYIubiquitination[1]
1565GAKVTERKQQLEKCLubiquitination[1]
2836GDFPAVQKQNDIHRAubiquitination[1]
2921RSADWQRKIDEALERubiquitination[1]
2982RGEIAPLKENVNRVNubiquitination[1]
3062ERAISPNKVPYYINHubiquitination[1]
3213DKYRYLFKQVASSTGubiquitination[1]
3301VAAAETAKHQAKCNIubiquitination[1]
3556AELIAEAKLLRQHKGubiquitination[1]
3577QILEDHNKQLESQLHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. 
Sequence Annotation
 DOMAIN 1 240 Actin-binding.
 DOMAIN 15 119 CH 1.
 DOMAIN 134 237 CH 2.
 REPEAT 341 449 Spectrin 1.
 REPEAT 450 558 Spectrin 2.
 REPEAT 561 669 Spectrin 3.
 REPEAT 721 830 Spectrin 4.
 REPEAT 832 936 Spectrin 5.
 REPEAT 945 1047 Spectrin 6.
 REPEAT 1050 1156 Spectrin 7.
 REPEAT 1159 1265 Spectrin 8.
 REPEAT 1268 1369 Spectrin 9.
 REPEAT 1370 1465 Spectrin 10.
 REPEAT 1470 1570 Spectrin 11.
 REPEAT 1573 1678 Spectrin 12.
 REPEAT 1681 1780 Spectrin 13.
 REPEAT 1781 1876 Spectrin 14.
 REPEAT 1879 1981 Spectrin 15.
 REPEAT 1994 2103 Spectrin 16.
 REPEAT 2106 2210 Spectrin 17.
 REPEAT 2213 2318 Spectrin 18.
 REPEAT 2319 2416 Spectrin 19.
 REPEAT 2468 2570 Spectrin 20.
 REPEAT 2573 2679 Spectrin 21.
 REPEAT 2682 2795 Spectrin 22.
 REPEAT 2801 2923 Spectrin 23.
 REPEAT 2928 3033 Spectrin 24.
 DOMAIN 3048 3081 WW.
 ZN_FING 3300 3347 ZZ-type.
 REGION 63 72 ANK2- and ANK-3 binding.
 REGION 1417 1915 Interaction with SYNM.
 REGION 3051 3401 Interaction with SYNM.
 REGION 3459 3511 Binds to SNTB1 (By similarity).
 MOD_RES 3476 3476 Phosphoserine (By similarity).
 MOD_RES 3605 3605 Phosphoserine (By similarity).
 MOD_RES 3606 3606 Phosphoserine (By similarity).
 MOD_RES 3610 3610 Phosphoserine (By similarity).
 MOD_RES 3616 3616 Phosphoserine (By similarity).
 MOD_RES 3617 3617 Phosphoserine.
 MOD_RES 3659 3659 Phosphoserine (By similarity).  
Keyword
 Actin-binding; Alternative splicing; Calcium; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; Synapse; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3678 AA 
Protein Sequence
MLWWEEVEDC YEREDVQKKT FTKWINAQFS KFGKQHIDNL FSDLQDGKRL LDLLEGLTGQ 60
KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV DGNHKLTLGL IWNIILHWQV 120
KNVMKTIMAG LQQTNSEKIL LSWVRQSTRN YPQVNVINFT SSWSDGLALN ALIHSHRPDL 180
FDWNSVVSQH SATQRLEHAF NIAKCQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP 240
QQVSIEAIQE VEMLPRTSSK VTREEHFQLH HQMHYSQQIT VSLAQGYEQT SSSPKPRFKS 300
YAFTQAAYVA TSDSTQSPYP SQHLEAPRDK SLDSSLMETE VNLDSYQTAL EEVLSWLLSA 360
EDTLRAQGEI SNDVEEVKEQ FHAHEGFMMD LTSHQGLVGN VLQLGSQLVG KGKLSEDEEA 420
EVQEQMNLLN SRWECLRVAS MEKQSKLHKV LMDLQNQKLK ELDDWLTKTE ERTKKMEEEP 480
FGPDLEDLKC QVQQHKVLQE DLEQEQVRVN SLTHMVVVVD ESSGDHATAA LEEQLKVLGD 540
RWANICRWTE DRWIVLQDIL LKWQHFTEEQ CLFSTWLSEK EDAMKNIQTS GFKDQNEMMS 600
SLHKISTLKI DLEKKKPTME KLSSLNQDLL SALKNKSVTQ KMEIWMENFA QRWDNLTQKL 660
EKSSAQISQA VTTTQPSLTQ TTVMETVTMV TTREQIMVKH AQEELPPPPP QKKRQITVDS 720
ELRKRLDVDI TELHSWITRS EAVLQSSEFA VYRKEGNISD LQEKVNAIAR EKAEKFRKLQ 780
DASRSAQALV EQMANEGVNA ESIRQASEQL NSRWTEFCQL LSERVNWLEY QTNIITFYNQ 840
LQQLEQMTTT AENLLKTQST TLSEPTAIKS QLKICKDEVN RLSALQPQIE QLKIQSLQLK 900
EKGQGPMFLD ADFVAFTNHF NHIFDGVRAK EKELQTIFDT LPPMRYQETM SSIRTWIQQS 960
ESKLSVPYLS VTEYEIMEER LGKLQALQSS LKEQQNGFNY LSDTVKEMAK KAPSEICQKY 1020
LSEFEEIEGH WKKLSSQLVE SCQKLEEHMN KLRKFQNHIK TLQKWMAEVD VFLKEEWPAL 1080
GDAEILKKQL KQCRLLVGDI QTIQPSLNSV NEGGQKIKSE AELEFASRLE TELRELNTQW 1140
DHICRQVYTR KEALKAGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE 1200
EMKRAKEEAL QKETKVKLLT ETVNSVIAHA PPSAQEALKK ELETLTTNYQ WLCTRLNGKC 1260
KTLEEVWACW HELLSYLEKA NKWLNEVELK LKTMENVPAG PEEITEVLES LENLMHHSEE 1320
NPNQIRLLAQ TLTDGGVMDE LINEELETFN SRWRELHEEA VRKQKLLEQS IQSAQEIEKS 1380
LHLIQESLEF IDKQLAAYIT DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKDANQ 1440
RVLSQIDVAQ KKLQDVSMKF RLFQKPANFE QRLEESKMIL DEVKMHLPAL ETKSVEQEVI 1500
QSQLSHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL KLHYNELGAK 1560
VTERKQQLEK CLKLSRKMRK EMNVLTEWLA ATDTELTKRS AVEGMPSNLD SEVAWGKATQ 1620
KEIEKQKAHL KSVTELGESL KMVLGKKETL VEDKLSLLNS NWIAVTSRVE EWLNLLLEYQ 1680
KHMETFDQNI EQITKWIIHA DELLDESEKK KPQQKEDILK RLKAEMNDMR PKVDSTRDQA 1740
AKLMANRGDH CRKVVEPQIS ELNRRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE 1800
AEIQQGVNLK EEDFNKDMSE DNEGTVNELL QRGDNLQQRI TDERKREEIK IKQQLLQTKH 1860
NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDEIEK KLASLPEPRD ERKLKEIDRE 1920
LQKKKEELNA VRRQAEGLSE NGAAMAVEPT QIQLSKRWRQ IESNFAQFRR LNFAQIHTLH 1980
EETMVVTTED MPLDVSYVPS TYLTEISHIL QALSEVDHLL NTPELCAKDF EDLFKQEESL 2040
KNIKDNLQQI SGRIDIIHKK KTAALQSATS MEKVKVQEAV AQMDFQGEKL HRMYKERQGR 2100
FDRSVEKWRH FHYDMKVFNQ WLNEVEQFFK KTQNPENWEH AKYKWYLKEL QDGIGQRQAV 2160
VRTLNATGEE IIQQSSKTDV NILQEKLGSL SLRWHDICKE LAERRKRIEE QKNVLSEFQR 2220
DLNEFVLWLE EADNIAITPL GDEQQLKEQL EQVKLLAEEL PLRQGILKQL NETGGAVLVS 2280
APIRPEEQDK LEKKLKQTNL QWIKVSRALP EKQGELEVHL KDFRQLEEQL DHLLLWLSPI 2340
RNQLEIYNQP SQAGPFDIKE IEVTVHGKQA DVERLLSKGQ HLYKEKPSTQ PVKRKLEDLR 2400
SEWEAVNHLL RELRTKQPDR APGLSTTGAS ASQTVTLVTQ SVVTKETVIS KLEMPSSLLL 2460
EVPALADFNR AWTELTDWLS LLDRVIKSQR VMVGDLEDIN EMIIKQKATL QDLEQRRPQL 2520
EELITAAQNL KNKTSNQEAR TIITDRIERI QIQWDEVQEQ LQNRRQQLNE MLKDSTQWLE 2580
AKEEAEQVIG QVRGKLDSWK EGPHTVDAIQ KKITETKQLA KDLRQRQISV DVANDLALKL 2640
LRDYSADDTR KVHMITENIN TSWGNIHKRV SEQEAALEET HRLLQQFPLD LEKFLSWITE 2700
AETTANVLQD ASRKEKLLED SRGVRELMKP WQDLQGEIET HTDIYHNLDE NGQKILRSLE 2760
GSDEAPLLQR RLDNMNFKWS ELQKKSLNIR SHLEASSDQW KRLHLSLQEL LVWLQLKDDE 2820
LSRQAPIGGD FPAVQKQNDI HRAFKRELKT KEPVIMSTLE TVRIFLTEQP LEGLEKLYQE 2880
PRELPPEERA QNVTRLLRKQ AEEVNAEWDK LNLRSADWQR KIDEALERLQ ELQEAADELD 2940
LKLRQAEVIK GSWQPVGDLL IDSLQDHLEK VKALRGEIAP LKENVNRVND LAHQLTTLGI 3000
QLSPYNLSTL EDLNTRWRLL QVAVEDRVRQ LHEAHRDFGP ASQHFLSTSV QGPWERAISP 3060
NKVPYYINHE TQTTCWDHPK MTELYQSLAD LNNVRFSAYR TAMKLRRLQK ALCLDLLSLS 3120
AACDALDQHN LKQNDQPMDI LQIINCLTTI YDRLEQEHNN LVNVPLCVDM CLNWLLNVYD 3180
TGRTGRIRVL SFKTGIISLC KAHLEDKYRY LFKQVASSTG FCDQRRLGLL LHDSIQIPRQ 3240
LGEVASFGGS NIEPSVRSCF QFANNKPEIE AALFLDWMRL EPQSMVWLPV LHRVAAAETA 3300
KHQAKCNICK ECPIIGFRYR SLKHFNYDIC QSCFFSGRVA KGHKMHYPMV EYCTPTTSGE 3360
DVRDFAKVLK NKFRTKRYFA KHPRMGYLPV QTVLEGDNME TPVTLINFWP VDSAPASSPQ 3420
LSHDDTHSRI EHYASRLAEM ENSNGSYLND SISPNESIDD EHLLIQHYCQ SLNQDSPLSQ 3480
PRSPAQILIS LESEERGELE RILADLEEEN RNLQAEYDRL KQQHEHKGLS PLPSPPEMMP 3540
TSPQSPRDAE LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPQAEAKVN 3600
GTTVSSPSTS LQRSDSSQPM LLRVVGSQTS ESMGEEDLLS PPQDTSTGLE EVMEQLNNSF 3660
PSSRGRNAPG KPMREDTM 3678 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0030055; C:cell-substrate junction; IDA:MGI.
 GO:0043034; C:costamere; IEA:Compara.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:MGI.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0044306; C:neuron projection terminus; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0043623; P:cellular protein complex assembly; IMP:BHF-UCL.
 GO:0034613; P:cellular protein localization; IMP:BHF-UCL.
 GO:0008065; P:establishment of blood-nerve barrier; IMP:MGI.
 GO:0060857; P:establishment of glial blood-brain barrier; IMP:MGI.
 GO:0046716; P:muscle cell homeostasis; IMP:MGI.
 GO:0048747; P:muscle fiber development; IGI:MGI.
 GO:0014904; P:myotube cell development; IMP:MGI.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL.
 GO:0045213; P:neurotransmitter receptor metabolic process; IMP:MGI.
 GO:0051647; P:nucleus localization; IMP:MGI.
 GO:0021629; P:olfactory nerve structural organization; IMP:MGI.
 GO:0043043; P:peptide biosynthetic process; IEA:Compara.
 GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:BHF-UCL.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:2000651; P:positive regulation of sodium ion transmembrane transporter activity; IMP:BHF-UCL.
 GO:0086001; P:regulation of cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IMP:BHF-UCL.
 GO:0090287; P:regulation of cellular response to growth factor stimulus; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IMP:BHF-UCL.
 GO:2000169; P:regulation of peptidyl-cysteine S-nitrosylation; IMP:BHF-UCL.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IMP:BHF-UCL.
 GO:0014809; P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; IMP:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:MGI.
 GO:1901385; P:regulation of voltage-gated calcium channel activity; IMP:BHF-UCL. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR016344; Dystrophin/utrophin.
 IPR011992; EF-hand-like_dom.
 IPR015153; EF-hand_dom_typ1.
 IPR015154; EF-hand_dom_typ2.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat.
 IPR001202; WW_dom.
 IPR000433; Znf_ZZ. 
Pfam
 PF00307; CH
 PF09068; efhand_1
 PF09069; efhand_2
 PF00435; Spectrin
 PF00397; WW
 PF00569; ZZ 
SMART
 SM00033; CH
 SM00150; SPEC
 SM00456; WW
 SM00291; ZnF_ZZ 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS