CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylosuccinate lyase 
Protein Synonyms/Alias
  
Gene Name
 ASL 
Gene Synonyms/Alias
 PFB0295w 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
409ADSYEQLKNFTRGKSacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MDVHVNQLKN ISPIDGRYKR SCQEVSEYFS EYALIKYRII VEIKWLLFLN DKEYFFPKVS 60
EKSLSNITSI MELINDNDIL RVKKIEEETN HDVKAVEYFI REKLESLKNE EITKVIPYVH 120
YLCTSEDINN IAYGLCLYNC IHNIIIPNIQ NIIDKLKEFS FNYSDVSLLS KTHGQPASPT 180
TFGKEMSNYY YRLYKHINKL KNIEIYVKFN GAVGNFNAHK VCDPNIDWID NIKYFIETYF 240
NLHFSLYCTQ IQDHDYICEI SDTLARLNYT LIDLSVDMWL YISSNVLKLK VIQKEIGSST 300
MPHKVNPIDF ENAEGNLHLA NSLFKLFSSK LPISRLQRDL SDSTVLRNLG SSFAYSLISY 360
KSLLRGLNKI DVDQNVMNEQ LNQNWCTLAE PIQIIMKKYN IADSYEQLKN FTRGKSIDKQ 420
CMYQFIQQNC SHLPKNAIDE LMNLTPHNYL GYASYLSKNV EHFSQEYIKK N 471 
Gene Ontology
 GO:0070626; F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; IEA:EC.
 GO:0004018; F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; IEA:EC.
 GO:0006188; P:IMP biosynthetic process; IEA:InterPro. 
Interpro
 IPR013539; AdenyloSucc_lyase_C_pln.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like.
 IPR004769; Pur_lyase. 
Pfam
 PF08328; ASL_C
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00149; FUMRATELYASE.