UniProt Accession

 ZDHC9_HUMAN; Q9Y397; B4F6G2; D3DTF9; Q59EK4; Q5JSW5; Q8WWS7; Q9BPY4; Q9NSP0; Q9NVL0; Q9NVR6 

Genbank Protein ID

 AY952881; AF151847; AY358558; AK001524; AK001424; AB209807; AL161962; AL034405; AL359542; AL359542; AL034405; CH471107; CH471107; CH471107; BC000035; BC003128; BC006200; BC012826 

Genbank Nucleotide ID

 ACF60379.1; AAD34084.1; AAQ88922.1; BAA91740.1; BAA91683.1; BAD93044.1; CAB82308.1; CAI42905.1; CAI42905.1; CAI42069.1; CAI42069.1; EAX11823.1; EAX11824.1; EAX11825.1; AAH00035.1; AAH03128.1; AAH06200.1; AAH12826.1 

Protein Name

 Palmitoyltransferase ZDHHC9 

Protein Synonyms/Alias

 Zinc finger DHHC domain-containing protein 9; DHHC-9; DHHC9; Zinc finger protein 379; Zinc finger protein 380 

Gene Name

 ZDHHC9 

Gene Synonyms/Alias

 CXorf11; ZDHHC10; ZNF379; ZNF380; CGI-89; UNQ261/PRO298 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	QRPPPRIKNFQINNQ	ubiquitination	[1, 2, 3]
281	YSHGNIVKNCCEVLC	ubiquitination	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. 

Sequence Annotation

 ZN_FING 139 189 DHHC-type.
 ACT_SITE 169 169 S-palmitoyl cysteine intermediate  

Keyword

 Acyltransferase; Complete proteome; Disease mutation; Endoplasmic reticulum; Golgi apparatus; Membrane; Mental retardation; Metal-binding; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR001594; Znf_DHHC_palmitoyltrfase. 

Pfam

 PF01529; zf-DHHC 

SMART

  

PROSITE

 PS50216; ZF_DHHC 

PRINTS