CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044359
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BTB (POZ) domain containing 5, isoform CRA_d 
Protein Synonyms/Alias
 Kelch-like protein 28 
Gene Name
 KLHL28 
Gene Synonyms/Alias
 BTBD5; hCG_20873 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246RLPLLSVKFLTRLYEubiquitination[1]
265IRDDRTCKHLLNEALubiquitination[1, 2]
297TRPRCAPKVLCAVGGubiquitination[1, 2]
365RPGVTIRKHENSVECubiquitination[1]
426KYIPKIRKWQPVAPMubiquitination[1]
527WTVCRPMKEPRTGVGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kelch repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 585 AA 
Protein Sequence
MHFKCKYSYP ALYQMDHTSP TYMLANLTHL HSEQLLQGLN LLRQHHELCD IILRVGDVKI 60
HAHKVVLASV SPYFKAMFTG NLSEKENSEV EFQCIDETAL QAIVEYAYTG TVFISQDTVE 120
SLLPAANLLQ IKLVLKECCA FLESQLDPGN CIGISRFAET YGCRDLYLAA TKYICQNFEA 180
VCQTEEFFEL THADLDEIVS NDCLNVATEE TVFYALESWI KYDVQERQKY LAQLLNSVRL 240
PLLSVKFLTR LYEANHLIRD DRTCKHLLNE ALKYHFMPEH RLSHQTVLMT RPRCAPKVLC 300
AVGGKSGLFA CLDSVEMYFP QNDSWIGLAP LNIPRYEFGI CVLDQKVYVI GGIATNVRPG 360
VTIRKHENSV ECWNPDTNTW TSLERMNESR STLGVVVLAG ELYALGGYDG QSYLQSVEKY 420
IPKIRKWQPV APMTTTRSCF AAAVLDGMIY AIGGYGPAHM NSVERYDPSK DSWEMVASMA 480
DKRIHFGVGV MLGFIFVVGG HNGVSHLSSI ERYDPHQNQW TVCRPMKEPR TGVGAAVIDN 540
YLYVVGGHSG SSYLNTVQKY DPISDTWLDS AGMIYCRCNF GLTAL 585 
Gene Ontology
  
Interpro
 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR017096; Kelch-like_gigaxonin.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 
PROSITE
 PS50097; BTB 
PRINTS