UniProt Accession

 CD63_HUMAN; P08962; F8VZE2; Q5TZP3; Q8N6Z9; Q9UCG6 

Genbank Protein ID

 X07982; M59907; M58485; S93788; X62654; AF508304; AK311893; CR542096; BT007073; BT020137; BT020138; AC009779; CH471054; BC002349; BC013017 

Genbank Nucleotide ID

 CAA30792.1; AAA63235.1; AAB21617.1; CAA44519.1; AAM34259.1; BAG34834.1; CAG46893.1; AAP35736.1; AAV38939.1; AAV38940.1; EAW96827.1; AAH02349.1; AAH13017.1 

Protein Name

 CD63 antigen 

Protein Synonyms/Alias

 Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63 

Gene Name

 CD63 

Gene Synonyms/Alias

 MLA1; TSPAN30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	AGYVFRDKVMSEFNN	ubiquitination	[1, 2, 3]
128	QQMENYPKNNHTASI	ubiquitination	[1, 2]
162	EKIPSMSKNRVPDSC	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation. 

Sequence Annotation

 CARBOHYD 130 130 N-linked (GlcNAc...).
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Endosome; Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:MGI.
 GO:0010008; C:endosome membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; TAS:ProtInc.
 GO:0031088; C:platelet dense granule membrane; TAS:Reactome.
 GO:0034613; P:cellular protein localization; IDA:MGI.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:2000680; P:regulation of rubidium ion transport; IDA:MGI. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.