UniProt Accession

 DNJB6_MOUSE; O54946; Q3TE94; Q3U6L0; Q3UNJ5; Q3UYT7; Q99LA5; Q9QYI9 

Genbank Protein ID

 AB028854; AF035962; AK133805; AK134387; AK144182; AK151219; AK151752; AK152626; AK152632; AK153091; AK169332; AK169767; BC003702; BC083349 

Genbank Nucleotide ID

 BAA88302.1; AAC16759.1; BAE21853.1; BAE22124.1; BAE25752.1; BAE30213.1; BAE30661.1; BAE31369.1; BAE31375.1; BAE31714.1; BAE41085.1; BAE41354.1; AAH03702.1; AAH83349.1 

Protein Name

 DnaJ homolog subfamily B member 6 

Protein Synonyms/Alias

 Heat shock protein J2; HSJ-2; MRJ; mDj4 

Gene Name

 Dnajb6 

Gene Synonyms/Alias

 Hsj2; Mrj 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	HASPEDIKKAYRKQA	ubiquitination	[1]
34	ALKWHPDKNPENKEE	ubiquitination	[1]
60	YEVLSDAKKRDIYDK	ubiquitination	[1]
197	KSISTSTKIVNGKKI	ubiquitination	[1]
226	VEEDGQLKSLTINGK	ubiquitination	[1]
233	KSLTINGKEHLLRLD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). 

Sequence Annotation

 DOMAIN 3 69 J.
 REGION 2 147 Interaction with HSP70 (By similarity).
 REGION 120 235 Interaction with KRT18 (By similarity).  

Keyword

 Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
 GO:0001671; F:ATPase activator activity; IEA:Compara.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
 GO:0060710; P:chorio-allantoic fusion; IMP:MGI.
 GO:0060717; P:chorion development; IMP:MGI.
 GO:0030198; P:extracellular matrix organization; IMP:MGI.
 GO:0045109; P:intermediate filament organization; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0034504; P:protein localization to nucleus; IMP:MGI.
 GO:0060715; P:syncytiotrophoblast cell differentiation involved in labyrinthine layer development; IMP:MGI. 

Interpro

 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS. 

Pfam

 PF00226; DnaJ 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.