CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromatin modification-related protein EAF5 
Protein Synonyms/Alias
 ESA1-associated factor 5 
Gene Name
 EAF5 
Gene Synonyms/Alias
 YEL018W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
3*****MDKEVSELVVacetylation[1]
Reference
 [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 
Functional Description
 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. 
Sequence Annotation
  
Keyword
 Chromatin regulator; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 279 AA 
Protein Sequence
MDKEVSELVV LQLIHTLISN KNEELVRNGG GINMIGNNLR ISLVKLTNEI QNNLLINELT 60
NLRRQSNVAN GNRKLGINDI LTIVKNLFPE YRTTLNDGQL SLHGLEMHDI EKLLDEKYDR 120
FKKTQVEQIR MMEDEILKNG IKTGASQLQP HANAGKSGSA GTSATITTTT PHMAHSMDPK 180
REKLLKLYRD TVLNKLESKT GNFQKLFKSP DGSIIKNEIN YEDIKNETPG SVHELQLILQ 240
KSITDGVMRK VIGTDDWKLA RQVQFELDDT VQFMRRALE 279 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IPI:SGD.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IDA:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR026226; EAF5. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02067; PROTEINEAF5.