Tag | Content |
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CPLM ID | CPLM-020840 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitric oxide synthase-interacting protein |
Protein Synonyms/Alias | |
Gene Name | Nosip |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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78 | LEYILHQKREIARQV | ubiquitination | [1] | 153 | PSVGPVGKDKDKALP | ubiquitination | [1] | 157 | PVGKDKDKALPSFWI | ubiquitination | [1] | 172 | PSLTPEAKATKLEKP | ubiquitination | [1] | 190 | VTCPMSGKPLRMSDL | ubiquitination | [1] | 289 | GFAGSGVKLQAEMSR | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). |
Sequence Annotation | REGION 55 75 U-box-like. MOTIF 78 101 Nuclear localization signal (By |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 301 AA |
Protein Sequence | MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60 DGYLYEREAI LEYILHQKRE IARQVKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120 IVSRPLNPFM PKAATLPNTE GEQPGPSVGP VGKDKDKALP SFWIPSLTPE AKATKLEKPS 180 RTVTCPMSGK PLRMSDLTSV RFTQLDDSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR 240 PSGAVVTLEC VEKLIRKDMV DPVNGDTLTE RDIIVLQRGG TGFAGSGVKL QAEMSRPVMQ 300 A 301 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |