UniProt Accession

 FRIH_HUMAN; P02794; B3KNR5; Q3KRA8; Q3SWW1 

Genbank Protein ID

 X00318; M11146; M12937; X03487; X03488; M14212; M14211; M97164; L20941; AF088851; AY258285; AB062402; AK054816; DQ496108; CH471076; BC000857; BC001399; BC011359; BC013724; BC015156; BC016009; BC016857; BC063514; BC066961; BC073750; BC104643; BC105802; M15383 

Genbank Nucleotide ID

 CAA25086.1; AAA52437.1; AAA35830.1; CAA27205.1; CAA27205.1; AAA52438.1; AAA52438.1; AAA35832.1; AAA35833.1; AAF89523.1; AAP82230.1; BAB93489.1; BAG51427.1; ABF47097.1; EAW73989.1; AAH00857.1; AAH01399.1; AAH11359.1; AAH13724.1; AAH15156.1; AAH16009.1; AAH16857.1; AAH63514.1; AAH66961.1; AAH73750.1; AAI04644.1; AAI05803.1; AAA52479.1 

Protein Name

 Ferritin heavy chain 

Protein Synonyms/Alias

 Ferritin H subunit; Cell proliferation-inducing gene 15 protein 

Gene Name

 FTH1 

Gene Synonyms/Alias

 FTH; FTHL6; OK/SW-cl.84; PIG15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	EHAEKLMKLQNQRGG	ubiquitination	[1]
147	NEQVKAIKELGDHVT	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). 

Sequence Annotation

 DOMAIN 11 160 Ferritin-like diiron.
 METAL 28 28 Iron 1.
 METAL 63 63 Iron 1.
 METAL 63 63 Iron 2.
 METAL 66 66 Iron 1.
 METAL 108 108 Iron 2.
 METAL 142 142 Iron 2.
 MOD_RES 179 179 Phosphoserine.
 MOD_RES 183 183 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Iron; Iron storage; Metal-binding; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008043; C:intracellular ferritin complex; TAS:ProtInc.
 GO:0008199; F:ferric iron binding; IEA:InterPro.
 GO:0004322; F:ferroxidase activity; IEA:EC.
 GO:0005506; F:iron ion binding; TAS:ProtInc.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006955; P:immune response; ISS:UniProtKB.
 GO:0006880; P:intracellular sequestering of iron ion; IDA:UniProtKB.
 GO:0006826; P:iron ion transport; IEA:InterPro.
 GO:0048147; P:negative regulation of fibroblast proliferation; IDA:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR001519; Ferritin.
 IPR009040; Ferritin-like_diiron.
 IPR009078; Ferritin-like_SF.
 IPR012347; Ferritin-rel.
 IPR014034; Ferritin_CS.
 IPR008331; Ferritin_DPS_dom. 

Pfam

 PF00210; Ferritin 

SMART

  

PROSITE

 PS00540; FERRITIN_1
 PS00204; FERRITIN_2
 PS50905; FERRITIN_LIKE 

PRINTS