UniProt Accession

 PGK2_HUMAN; P07205; B2R6Y8; Q9H107 

Genbank Protein ID

 X05246; AK312770; AL121974; BC038843 

Genbank Nucleotide ID

 CAA28872.1; BAG35635.1; CAC19655.1; AAH38843.1 

Protein Name

 Phosphoglycerate kinase 2 

Protein Synonyms/Alias

 Phosphoglycerate kinase, testis specific 

Gene Name

 PGK2 

Gene Synonyms/Alias

 PGKB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	DFNVPMKKNQITNNQ	acetylation	[1]
267	EEGAKIVKDIMAKAQ	acetylation	[2]
267	EEGAKIVKDIMAKAQ	ubiquitination	[3]
388	AKWNTEDKVSHVSTG	ubiquitination	[3]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 NP_BIND 373 376 ATP (By similarity).
 REGION 24 26 Substrate binding (By similarity).
 REGION 63 66 Substrate binding (By similarity).
 BINDING 39 39 Substrate (By similarity).
 BINDING 123 123 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 220 220 ATP (By similarity).
 BINDING 313 313 ATP; via carbonyl oxygen (By similarity).
 BINDING 344 344 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB.
 GO:0006096; P:glycolysis; NAS:UniProtKB. 

Interpro

 IPR001576; Phosphoglycerate_kinase.
 IPR015901; Phosphoglycerate_kinase_C.
 IPR015911; Phosphoglycerate_kinase_CS.
 IPR015824; Phosphoglycerate_kinase_N. 

Pfam

 PF00162; PGK 

SMART

  

PROSITE

 PS00111; PGLYCERATE_KINASE 

PRINTS

 PR00477; PHGLYCKINASE.