CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative cysteine synthase 
Protein Synonyms/Alias
 CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase 
Gene Name
 YGR012W 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
86CNPAGSAKDRVALNIubiquitination[1]
161GATVNKVKPASIVDPubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
 REGION 230 234 Pyridoxal phosphate binding (By
 BINDING 338 338 Pyridoxal phosphate (By similarity).
 MOD_RES 86 86 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MSCSQNKTSV SLAWRECISI ASVLIGAYAS YKYYKLFKTR DIPRPKEGVE ELIGNTPLVK 60
IRSLTKATGV NIYAKLELCN PAGSAKDRVA LNIIKTAEEL GELVRGEPGW VFEGTSGSTG 120
ISIAVVCNAL GYRAHISLPD DTSLEKLALL ESLGATVNKV KPASIVDPNQ YVNAAKKACN 180
ELKKSGNGIR AVFADQFENE ANWKVHYQTT GPEIAHQTKG NIDAFIAGCG TGGTITGVAK 240
FLKERAKIPC HVVLADPQGS GFYNRVNYGV MYDYVEKEGT RRRHQVDTIV EGIGLNRITH 300
NFHMGEKFID ESIRVNDNQA IRMAKYLSVN DGLFVGSSTA INAVAAIQVA KTLPHGSNIV 360
IIACDSGSRH LSKFWKEAKE IDHDVSLEEV INI 393 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0004124; F:cysteine synthase activity; IEA:EC.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro. 
Interpro
 IPR001216; Cys_synth_BS.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00291; PALP 
SMART
  
PROSITE
 PS00901; CYS_SYNTHASE 
PRINTS