UniProt Accession

 AP2C_HUMAN; Q92754; O00685; O00730; Q86V30; Q8IVB6; Q9P1X2 

Genbank Protein ID

 X95693; U85658; AJ315934; AL121920; BC035664; BC051829; AB041717 

Genbank Nucleotide ID

 CAA64989.1; AAC51305.1; CAC86997.1; CAC10334.1; AAH35664.2; AAH51829.2; BAC11805.1 

Protein Name

 Transcription factor AP-2 gamma 

Protein Synonyms/Alias

 AP2-gamma; Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1 

Gene Name

 TFAP2C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
241	LSSTSKYKVTVAEVQ	ubiquitination	[1]
281	GGRSLREKLDKIGLN	ubiquitination	[1]
284	SLREKLDKIGLNLPA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. 

Sequence Annotation

 REGION 293 424 H-S-H (helix-span-helix), dimerization.
 MOTIF 59 64 WW-binding.
 MOD_RES 252 252 Phosphoserine; by PKA (By similarity).
 MOD_RES 434 434 Phosphoserine.
 CROSSLNK 10 10 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 450 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0046983; F:protein dimerization activity; IDA:UniProtKB.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0060598; P:dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IEA:Compara.
 GO:0021877; P:forebrain neuron fate commitment; IEA:Compara.
 GO:0030718; P:germ-line stem cell maintenance; IEA:Compara.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0003334; P:keratinocyte development; IEA:Compara.
 GO:0008584; P:male gonad development; IEP:UniProtKB.
 GO:0045682; P:regulation of epidermis development; IEA:Compara.
 GO:0048733; P:sebaceous gland development; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IEA:Compara. 

Interpro

 IPR004979; TF_AP2.
 IPR013854; TF_AP2_C.
 IPR008123; TF_AP2_gamma. 

Pfam

 PF03299; TF_AP-2 

SMART

  

PROSITE

  

PRINTS

 PR01751; AP2CTNSCPFCT.
 PR01748; AP2TNSCPFCT.