CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015462
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinate phosphoribosyltransferase 
Protein Synonyms/Alias
 NAPRTase; FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1 
Gene Name
 NAPRT1 
Gene Synonyms/Alias
 FHIP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
421KQTLPGSKAAFRLLGubiquitination[1]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. 
Sequence Annotation
 MOD_RES 537 537 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Ligase; Phosphoprotein; Polymorphism; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
MAAEQDPEAR AAARPLLTDL YQATMALGYW RAGRARDAAE FELFFRRCPF GGAFALAAGL 60
RDCVRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD CSEVTVRALP EGSLAFPGVP 120
LLQVSGPLLV VQLLETPLLC LVSYASLVAT NAARLRLIAG PEKRLLEMGL RRAQGPDGGL 180
TASTYSYLGG FDSSSNVLAG QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APAAGEGPGV 240
DLAAKAQVWL EQVCAHLGLG VQEPHPGERA AFVAYALAFP RAFQGLLDTY SVWRSGLPNF 300
LAVALALGEL GYRAVGVRLD SGDLLQQAQE IRKVFRAAAA QFQVPWLESV LIVVSNNIDE 360
EALARLAQEG SEVNVIGIGT SVVTCPQQPS LGGVYKLVAV GGQPRMKLTE DPEKQTLPGS 420
KAAFRLLGSD GSPLMDMLQL AEEPVPQAGQ ELRVWPPGAQ EPCTVRPAQV EPLLRLCLQQ 480
GQLCEPLPSL AESRALAQLS LSRLSPEHRR LRSPAQYQVV LSERLQALVN SLCAGQSP 538 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IDA:UniProtKB.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019674; P:NAD metabolic process; TAS:Reactome.
 GO:0006769; P:nicotinamide metabolic process; TAS:Reactome.
 GO:0019358; P:nicotinate nucleotide salvage; IEA:InterPro.
 GO:0006979; P:response to oxidative stress; IMP:UniProtKB.
 GO:0006767; P:water-soluble vitamin metabolic process; TAS:Reactome. 
Interpro
 IPR015977; Nic_PRibTrfase-like.
 IPR007229; Nic_PRibTrfase-rel.
 IPR006405; Nic_PRibTrfase_put.
 IPR002638; Quinolinate_PRibosylTrfase_C. 
Pfam
 PF04095; NAPRTase 
SMART
  
PROSITE
  
PRINTS