UniProt Accession

 HEXI1_RAT; Q5M9G1 

Genbank Protein ID

 BC087133 

Genbank Nucleotide ID

 AAH87133.1 

Protein Name

 Protein HEXIM1 

Protein Synonyms/Alias

 Cardiac lineage protein 1 

Gene Name

 Hexim1 

Gene Synonyms/Alias

 Clp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
162	SKKKRHWKPYYKLTW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (By similarity). 

Sequence Annotation

 REGION 147 174 Basic region; mediates nuclear
 REGION 199 202 Interaction with P-TEFb (By similarity).
 REGION 207 247 Autoinhibitory acidic region; in absence
 REGION 283 311 Mediates interaction with CCNT1 (By
 REGION 307 352 Required for inhibition of ESR1-dependent
 MOD_RES 98 98 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).
 MOD_RES 233 233 Phosphothreonine (By similarity).
 MOD_RES 234 234 Phosphoserine (By similarity).
 MOD_RES 249 249 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 356 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISS:UniProtKB.
 GO:0017069; F:snRNA binding; ISS:UniProtKB.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR024872; HEXIM. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02094; HEXIMFAMILY.