| Tag | Content |
|---|
| CPLM ID | CPLM-013235 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptic vesicle glycoprotein 2C |
Protein Synonyms/Alias | |
Gene Name | SV2C |
Gene Synonyms/Alias | KIAA1054 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 113 | IVSVGQPKGDEYKDR | ubiquitination | [1] | | 376 | RARGQPEKVFTVNKI | ubiquitination | [1] | | 382 | EKVFTVNKIKTPKQI | ubiquitination | [1] | | 387 | VNKIKTPKQIDELIE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). |
Sequence Annotation | REGION 1 57 Interaction with SYT1 (By similarity).
CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
CARBOHYD 484 484 N-linked (GlcNAc...) (Potential).
CARBOHYD 534 534 N-linked (GlcNAc...) (Potential).
CARBOHYD 559 559 N-linked (GlcNAc...) (Potential).
CARBOHYD 565 565 N-linked (GlcNAc...) (Potential). |
Keyword | Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Neurotransmitter transport; Polymorphism; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 727 AA |
Protein Sequence | MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP 60
AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN QAKDSIVSVG QPKGDEYKDR 120
RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE 180
TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG 240
YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI 300
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL 360
KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT 420
FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL SVWFPDVIKP LQSDEYALLT RNVERDKYAN 480
FTINFTMENQ IHTGMEYDNG RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT 540
VFDNTDFEPY KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS 600
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE 660
LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP ILLASTVLVC GGLVGLCLPD 720
TRTQVLM 727 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0022857; F:transmembrane transporter activity; IEA:InterPro. GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |