UniProt Accession

 AP1M1_HUMAN; Q9BXS5; Q4TTY5 

Genbank Protein ID

 AF290613; DQ059565; AC020911; BC017469 

Genbank Nucleotide ID

 AAK28024.1; AAY54246.1; AAH17469.1 

Protein Name

 AP-1 complex subunit mu-1 

Protein Synonyms/Alias

 AP-mu chain family member mu1A; Adaptor protein complex AP-1 mu-1 subunit; Adaptor-related protein complex 1 mu-1 subunit; Clathrin assembly protein complex 1 medium chain 1; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin 

Gene Name

 AP1M1 

Gene Synonyms/Alias

 CLTNM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	AVYVLDLKGKVLICR	ubiquitination	[1]
14	YVLDLKGKVLICRNY	ubiquitination	[1]
141	YITQEGHKLETGAPR	ubiquitination	[1]
211	SEIVGSIKMRVFLSG	ubiquitination	[1]
229	LRLGLNDKVLFDNTG	ubiquitination	[1]
241	NTGRGKSKSVELEDV	ubiquitination	[1]
249	SVELEDVKFHQCVRL	ubiquitination	[1]
336	PNDADSPKFKTTVGS	ubiquitination	[1]
338	DADSPKFKTTVGSVK	ubiquitination	[1]
345	KTTVGSVKWVPENSE	ubiquitination	[1]
358	SEIVWSIKSFPGGKE	ubiquitination	[1]
408	GIQVRYLKIIEKSGY	ubiquitination	[1]
412	RYLKIIEKSGYQALP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 

Sequence Annotation

 DOMAIN 168 421 MHD.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 152 152 Phosphothreonine (By similarity).
 MOD_RES 154 154 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Golgi apparatus; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0035646; P:endosome to melanosome transport; IMP:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0032438; P:melanosome organization; IMP:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 

PRINTS

 PR00314; CLATHRINADPT.