UniProt Accession

 OTC_RAT; P00481; Q63407 

Genbank Protein ID

 K03040; M16933; M16924; M16925; M16926; M16928; M16929; M16930; M16932; X01976; K00001; M11266; X01178 

Genbank Nucleotide ID

 AAA41768.1; AAA41769.1; AAA41769.1; AAA41769.1; AAA41769.1; AAA41769.1; AAA41769.1; AAA41769.1; AAA41769.1; CAA26007.1; AAA41772.1; AAA41767.1; CAA25618.1 

Protein Name

 Ornithine carbamoyltransferase, mitochondrial 

Protein Synonyms/Alias

 Ornithine transcarbamylase; OTCase 

Gene Name

 Otc 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
70	LKFRIKQKGEYLPLL	acetylation	[1]
88	SLGMIFEKRSTRTRL	acetylation	[1]
144	AVLARVYKQSDLDIL	acetylation	[1]
221	HLQAATPKGYEPDPN	acetylation	[1]
231	EPDPNIVKLAEQYAK	acetylation	[1]
238	KLAEQYAKENGTRLS	acetylation	[1]
307	FLHCLPRKPEEVDDE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 REGION 90 94 Ornithine and carbamoyl phosphate binding
 REGION 168 171 Ornithine and carbamoyl phosphate binding
 REGION 263 267 Ornithine binding (By similarity).
 REGION 302 305 Ornithine binding (By similarity).
 ACT_SITE 303 303 By similarity.
 BINDING 141 141 Carbamoyl phosphate (By similarity).
 BINDING 141 141 Ornithine (By similarity).
 BINDING 168 168 Carbamoyl phosphate (By similarity).
 BINDING 199 199 Ornithine (By similarity).
 BINDING 330 330 Carbamoyl phosphate (By similarity).
 BINDING 330 330 Ornithine (By similarity).
 MOD_RES 88 88 N6-acetyllysine (By similarity).
 MOD_RES 231 231 N6-acetyllysine (By similarity).
 MOD_RES 238 238 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Transferase; Transit peptide; Urea cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0016597; F:amino acid binding; IMP:RGD.
 GO:0004585; F:ornithine carbamoyltransferase activity; IDA:RGD.
 GO:0042301; F:phosphate ion binding; IMP:RGD.
 GO:0005543; F:phospholipid binding; IDA:RGD.
 GO:0055081; P:anion homeostasis; IDA:RGD.
 GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.
 GO:0019240; P:citrulline biosynthetic process; IDA:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0007494; P:midgut development; IEP:RGD.
 GO:0070207; P:protein homotrimerization; IDA:RGD.
 GO:0070781; P:response to biotin; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0000050; P:urea cycle; IDA:RGD. 

Interpro

 IPR006132; Asp/Orn_carbamoyltranf_P-bd.
 IPR006130; Asp/Orn_carbamoylTrfase.
 IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
 IPR002292; Orn/put_carbamltrans. 

Pfam

 PF00185; OTCace
 PF02729; OTCace_N 

SMART

  

PROSITE

 PS00097; CARBAMOYLTRANSFERASE 

PRINTS

 PR00100; AOTCASE.
 PR00102; OTCASE.