UniProt Accession

 ANLN_HUMAN; Q9NQW6; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NVN9; Q9NVP0 

Genbank Protein ID

 AF273437; BC034692; BC070066; CR936650; AK001468; AK001472; AK023208 

Genbank Nucleotide ID

 AAF75796.1; AAH34692.1; AAH70066.1; CAI56788.1; BAA91710.1; BAA91711.1; BAB14463.1 

Protein Name

 Actin-binding protein anillin 

Protein Synonyms/Alias

  

Gene Name

 ANLN 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
371	TPGGTGIKPFLERFG	acetylation	[1, 2]
491	QSLPVTEKVTENQIP	acetylation	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. 

Sequence Annotation

 DOMAIN 983 1107 PH.
 REGION 1 230 Nuclear localization.
 REGION 1 155 Interaction with CD2AP.
 REGION 1 45 Required for ubiquitination.
 REGION 231 676 Interaction with F-actin.
 REGION 730 1124 Localization to the cleavage furrow.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 72 72 Phosphoserine.
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 172 172 Phosphoserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 194 194 Phosphothreonine.
 MOD_RES 320 320 Phosphothreonine.
 MOD_RES 323 323 Phosphoserine.
 MOD_RES 364 364 Phosphothreonine.
 MOD_RES 371 371 N6-acetyllysine.
 MOD_RES 397 397 Phosphothreonine.
 MOD_RES 401 401 Phosphothreonine.
 MOD_RES 449 449 Phosphoserine.
 MOD_RES 485 485 Phosphoserine.
 MOD_RES 515 515 Phosphothreonine (By similarity).
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 553 553 Phosphoserine.
 MOD_RES 561 561 Phosphoserine.
 MOD_RES 642 642 Phosphoserine.
 MOD_RES 658 658 Phosphoserine.
 MOD_RES 661 661 Phosphoserine.
 MOD_RES 664 664 Phosphoserine.
 MOD_RES 792 792 Phosphoserine.
 MOD_RES 927 927 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1124 AA 

Protein Sequence

Gene Ontology

 GO:0005826; C:actomyosin contractile ring; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0000910; P:cytokinesis; IDA:MGI.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007096; P:regulation of exit from mitosis; TAS:ProtInc.
 GO:0000921; P:septin ring assembly; TAS:ProtInc. 

Interpro

 IPR012966; DUF1709.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF08174; Anillin
 PF00169; PH 

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS